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Disruption in cerebellar and basal ganglia networks during a visuospatial task in cervical dystonia
P. Filip, C. Gallea, S. Lehéricy, E. Bertasi, T. Popa, R. Mareček, OV. Lungu, T. Kašpárek, J. Vaníček, M. Bareš,
Language English Country United States
Document type Journal Article
PubMed
28186664
DOI
10.1002/mds.26930
Knihovny.cz E-resources
- MeSH
- Basal Ganglia diagnostic imaging physiopathology MeSH
- Adult MeSH
- Functional Neuroimaging MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Young Adult MeSH
- Motor Cortex diagnostic imaging physiopathology MeSH
- Cerebellum diagnostic imaging physiopathology MeSH
- Brain diagnostic imaging physiopathology MeSH
- Neural Pathways diagnostic imaging physiopathology MeSH
- Task Performance and Analysis MeSH
- Image Processing, Computer-Assisted MeSH
- Spatial Processing * MeSH
- Torticollis diagnostic imaging physiopathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. METHODS: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients (n = 25, 15 women, mean age 45.8 years) and healthy volunteers (n = 25, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. RESULTS: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. CONCLUSIONS: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. © 2017 International Parkinson and Movement Disorder Society.
Department of Imaging Methods Masaryk University and St Anne's Teaching Hospital Brno Czech Republic
References provided by Crossref.org
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- $a Filip, Pavel $u Central European Institute of Technology, Central European Institute of Technology, Masaryk University (CEITEC MU), Behavioral and Social Neuroscience Research Group, Masaryk University, Brno, Czech Republic. First Department of Neurology, Faculty of Medicine, Masaryk University and St. Anne's Teaching Hospital, Brno, Czech Republic.
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- $a BACKGROUND: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. METHODS: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients (n = 25, 15 women, mean age 45.8 years) and healthy volunteers (n = 25, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. RESULTS: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. CONCLUSIONS: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. © 2017 International Parkinson and Movement Disorder Society.
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