Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

M. Raudenska, V. Dvorakova, L. Pacal, K. Chalasova, M. Kratochvilova, J. Gumulec, B. Ruttkay-Nedecky, O. Zitka, K. Kankova, V. Adam, M. Masarik,

. 2017 ; 31 (6) : . [pub] 20170106

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc18016822

Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18016822
003      
CZ-PrNML
005      
20180516135410.0
007      
ta
008      
180515s2017 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/jbt.21891 $2 doi
035    __
$a (PubMed)28059470
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Raudenska, Martina $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic. Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
245    10
$a Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease / $c M. Raudenska, V. Dvorakova, L. Pacal, K. Chalasova, M. Kratochvilova, J. Gumulec, B. Ruttkay-Nedecky, O. Zitka, K. Kankova, V. Adam, M. Masarik,
520    9_
$a Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a biologické markery $x krev $7 D015415
650    _2
$a studie případů a kontrol $7 D016022
650    _2
$a měď $x krev $7 D003300
650    _2
$a Česká republika $7 D018153
650    _2
$a diabetes mellitus 2. typu $x komplikace $7 D003924
650    _2
$a diabetické nefropatie $x krev $x genetika $x patofyziologie $7 D003928
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a genetické asociační studie $7 D056726
650    _2
$a lidé $7 D006801
650    _2
$a ledviny $x patofyziologie $7 D007668
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a metalothionein $x krev $x genetika $7 D008668
650    _2
$a lidé středního věku $7 D008875
650    12
$a oxidační stres $7 D018384
650    _2
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a chronická renální insuficience $x krev $x genetika $x patofyziologie $7 D051436
650    _2
$a stupeň závažnosti nemoci $7 D012720
650    _2
$a zinek $x krev $7 D015032
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Dvorakova, Veronika $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
700    1_
$a Pacal, Lukas $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
700    1_
$a Chalasova, Katarina $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
700    1_
$a Kratochvilova, Monika $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
700    1_
$a Gumulec, Jaromir $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic. Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
700    1_
$a Ruttkay-Nedecky, Branislav $u Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno, Czech Republic. Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
700    1_
$a Zitka, Ondrej $u Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno, Czech Republic. Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
700    1_
$a Kankova, Katerina $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
700    1_
$a Adam, Vojtech $u Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno, Czech Republic. Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
700    1_
$a Masarik, Michal $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
773    0_
$w MED00007458 $t Journal of biochemical and molecular toxicology $x 1099-0461 $g Roč. 31, č. 6 (2017)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28059470 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180515 $b ABA008
991    __
$a 20180516135545 $b ABA008
999    __
$a ok $b bmc $g 1300446 $s 1013662
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 31 $c 6 $e 20170106 $i 1099-0461 $m Journal of biochemical and molecular toxicology $n J Biochem Mol Toxicol $x MED00007458
LZP    __
$a Pubmed-20180515

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace