• Je něco špatně v tomto záznamu ?

H+ translocation by weak acid uncouplers is independent of H+ electrochemical gradient

J. Plášek, D. Babuka, M. Hoefer,

. 2017 ; 49 (5) : 391-397. [pub] 20170912

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18024654
E-zdroje Online Plný text

NLK ProQuest Central od 1997-02-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2011-02-01 do Před 1 rokem
Health & Medicine (ProQuest) od 1997-02-01 do Před 1 rokem

Odkazy

PubMed 28900787
DOI 10.1007/s10863-017-9724-x
Knihovny.cz E-zdroje

According to the common view, weak acid uncouplers increase proton conductance of biological (and phospholipid bilayer) membranes, thus effecting H+ fluxes driven by their electrochemical gradients. Under certain conditions, however, uncouplers can induce unexpected effects opposite to the dissipation of H+ gradients. Results are presented here demonstrating CCCP-induced proton influx into Saccharomyces cerevisiae cytosol driven by the electrochemical potentials of CCCP and its CCCP- anions, independent of electrochemical H+-gradient. Another view of week acid uncouplers' action is proposed that is logically consistent with these observations.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18024654
003      
CZ-PrNML
005      
20180716121854.0
007      
ta
008      
180709s2017 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s10863-017-9724-x $2 doi
035    __
$a (PubMed)28900787
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Plášek, Jaromír $u Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, 12116, Prague, Czech Republic. plasek@karlov.mff.cuni.cz.
245    10
$a H+ translocation by weak acid uncouplers is independent of H+ electrochemical gradient / $c J. Plášek, D. Babuka, M. Hoefer,
520    9_
$a According to the common view, weak acid uncouplers increase proton conductance of biological (and phospholipid bilayer) membranes, thus effecting H+ fluxes driven by their electrochemical gradients. Under certain conditions, however, uncouplers can induce unexpected effects opposite to the dissipation of H+ gradients. Results are presented here demonstrating CCCP-induced proton influx into Saccharomyces cerevisiae cytosol driven by the electrochemical potentials of CCCP and its CCCP- anions, independent of electrochemical H+-gradient. Another view of week acid uncouplers' action is proposed that is logically consistent with these observations.
650    _2
$a biologický transport $x účinky léků $7 D001692
650    _2
$a karbonylkyanid-m-chlorfenylhydrazon $x farmakologie $7 D002258
650    _2
$a koncentrace vodíkových iontů $x účinky léků $7 D006863
650    12
$a membránové potenciály $x účinky léků $7 D008564
650    12
$a protony $7 D011522
650    _2
$a Saccharomyces cerevisiae $x metabolismus $7 D012441
650    _2
$a rozpřahující látky $x farmakologie $7 D014475
655    _2
$a časopisecké články $7 D016428
700    1_
$a Babuka, David $u Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, 12116, Prague, Czech Republic.
700    1_
$a Hoefer, Milan $u Institute of Cellular and Molecular Botany, University of Bonn, Kirschallee 1, 53115, Bonn, Germany.
773    0_
$w MED00002541 $t Journal of bioenergetics and biomembranes $x 1573-6881 $g Roč. 49, č. 5 (2017), s. 391-397
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28900787 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180709 $b ABA008
991    __
$a 20180716122152 $b ABA008
999    __
$a ok $b bmc $g 1316785 $s 1021575
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 49 $c 5 $d 391-397 $e 20170912 $i 1573-6881 $m Journal of bioenergetics and biomembranes $n J Bioenerg Biomembr $x MED00002541
LZP    __
$a Pubmed-20180709

Najít záznam

Citační ukazatele

Možnosti archivace