Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs

B. Flahou, M. Rossi, J. Bakker, JA. Langermans, E. Heuvelman, JV. Solnick, ME. Martin, J. O'Rourke, LD. Ngoan, NX. Hoa, M. Nakamura, A. Øverby, H. Matsui, H. Ota, T. Matsumoto, DL. Foss, LA. Kopta, O. Omotosho, MP. Franciosini, P. Casagrande...

. 2018 ; 12 (1) : 77-86. [pub] 20170908

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc18024672

Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys. The origin of modern human-, pig- or non-human primate-associated H. suis strains in these respective host populations was hitherto unknown. Here we show that H. suis in pigs possibly originates from non-human primates. Our data suggest that a host jump from macaques to pigs happened between 100 000 and 15 000 years ago and that pig domestication has had a significant impact on the spread of H. suis in the pig population, from where this pathogen occasionally infects humans. Thus, in contrast to our expectations, H. suis appears to have evolved in its main host in a completely different way than its close relative Helicobacter pylori in humans.

Animal Science Department Biomedical Primate Research Centre Rijswijk The Netherlands

Department of Food Hygiene and Environmental Health Faculty of Veterinary Medicine University of Helsinki Helsinki Finland

Department of Laboratory Medicine Shinshu University Hospital Nagano Japan

Department of Mathematics and Statistics University of Helsinki Helsinki Finland Department of Biostatistics University of Oslo Oslo Norway

Department of Medical Biochemistry and Cell Biology University of Gothenburg Gothenburg Sweden

Department of Microbiology and Molecular Genetics University of California Davis CA USA

Department of Pathology Bacteriology and Avian Diseases Faculty of Veterinary Medicine Ghent University Ghent Belgium

Department of Veterinary Medicine Faculty of Veterinary Medicine University of Ibadan Ibadan Nigeria

Department of Veterinary Medicine University of Perugia Perugia Italy

Departments of Medicine and Microbiology and Immunology Center for Comparative Medicine University of California Davis CA USA

Faculty of Animal Science University of Agriculture and Forestry Hue University Hue City Vietnam

Kitasato Institute for Life Sciences and Graduate School of Control Sciences Kitasato University Tokyo Japan

Laboratory of Animal Pathology Department of Preventive Veterinary Medicine Universidade Estadual de Londrina Londrina Paraná Brazil

Laboratory of Experimental Medicine and Pediatrics University of Antwerp Antwerp Belgium

School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney New South Wales Australia

School of Health Sciences Shinshu University School of Medicine Nagano Japan

School of Pharmaceutical Sciences Kitasato University Tokyo Japan

The State Key Laboratory of Agricultural Microbiology Huazhong Agricultural University Wuhan China

University of Veterinary and Pharmaceutical Sciences Brno Faculty of Veterinary Hygiene and Ecology Department of Meat Hygiene and Technology Brno Czech Republic

Zoetis Kalamazoo MI USA

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18024672
003      
CZ-PrNML
005      
20180718102552.0
007      
ta
008      
180709s2018 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/ismej.2017.145 $2 doi
035    __
$a (PubMed)28885626
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Flahou, Bram $u Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
245    10
$a Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs / $c B. Flahou, M. Rossi, J. Bakker, JA. Langermans, E. Heuvelman, JV. Solnick, ME. Martin, J. O'Rourke, LD. Ngoan, NX. Hoa, M. Nakamura, A. Øverby, H. Matsui, H. Ota, T. Matsumoto, DL. Foss, LA. Kopta, O. Omotosho, MP. Franciosini, P. Casagrande Proietti, A. Guo, H. Liu, G. Borilova, AP. Bracarense, SK. Lindén, S. De Bruyckere, G. Zhang, C. De Witte, A. Smet, F. Pasmans, R. Ducatelle, J. Corander, F. Haesebrouck,
520    9_
$a Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys. The origin of modern human-, pig- or non-human primate-associated H. suis strains in these respective host populations was hitherto unknown. Here we show that H. suis in pigs possibly originates from non-human primates. Our data suggest that a host jump from macaques to pigs happened between 100 000 and 15 000 years ago and that pig domestication has had a significant impact on the spread of H. suis in the pig population, from where this pathogen occasionally infects humans. Thus, in contrast to our expectations, H. suis appears to have evolved in its main host in a completely different way than its close relative Helicobacter pylori in humans.
650    _2
$a zvířata $7 D000818
650    _2
$a hospodářská zvířata $x mikrobiologie $7 D000829
650    _2
$a infekce vyvolané Helicobacter pylori $x mikrobiologie $x veterinární $7 D016481
650    _2
$a Helicobacter heilmannii $x klasifikace $x genetika $x růst a vývoj $x izolace a purifikace $7 D018247
650    _2
$a lidé $7 D006801
650    _2
$a Macaca fascicularis $x mikrobiologie $7 D008252
650    _2
$a Macaca mulatta $x mikrobiologie $7 D008253
650    _2
$a fylogeneze $7 D010802
650    _2
$a žaludek $x mikrobiologie $7 D013270
650    _2
$a prasata $7 D013552
650    _2
$a nemoci prasat $x mikrobiologie $7 D013553
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Rossi, Mirko $u Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
700    1_
$a Bakker, Jaco $u Animal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
700    1_
$a Langermans, Jan Am $u Animal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
700    1_
$a Heuvelman, Edwin $u Animal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
700    1_
$a Solnick, Jay V $u Departments of Medicine and Microbiology & Immunology, Center for Comparative Medicine, University of California, Davis, CA, USA.
700    1_
$a Martin, Miriam E $u Department of Microbiology and Molecular Genetics, University of California, Davis, CA, USA.
700    1_
$a O'Rourke, Jani $u School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.
700    1_
$a Ngoan, Le Duc $u Faculty of Animal Science, University of Agriculture & Forestry, Hue University, Hue City, Vietnam.
700    1_
$a Hoa, Nguyen Xuan $u Faculty of Animal Science, University of Agriculture & Forestry, Hue University, Hue City, Vietnam.
700    1_
$a Nakamura, Masahiko $u School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
700    1_
$a Øverby, Anders $u School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
700    1_
$a Matsui, Hidenori $u Kitasato Institute for Life Sciences and Graduate School of Control Sciences, Kitasato University, Tokyo, Japan.
700    1_
$a Ota, Hiroyoshi $u School of Health Sciences, Shinshu University School of Medicine, Nagano, Japan.
700    1_
$a Matsumoto, Takehisa $u Department of Laboratory Medicine, Shinshu University Hospital, Nagano, Japan.
700    1_
$a Foss, Dennis L $u Zoetis, Kalamazoo, MI, USA.
700    1_
$a Kopta, Laurice A $u Zoetis, Kalamazoo, MI, USA.
700    1_
$a Omotosho, Oladipo $u Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
700    1_
$a Franciosini, Maria Pia $u Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
700    1_
$a Casagrande Proietti, Patrizia $u Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
700    1_
$a Guo, Aizhen $u The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
700    1_
$a Liu, Han $u The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
700    1_
$a Borilova, Gabriela $u University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Meat Hygiene and Technology, Brno, Czech Republic.
700    1_
$a Bracarense, Ana Paula $u Laboratory of Animal Pathology, Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
700    1_
$a Lindén, Sara K $u Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
700    1_
$a De Bruyckere, Sofie $u Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
700    1_
$a Zhang, Guangzhi $u Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
700    1_
$a De Witte, Chloë $u Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
700    1_
$a Smet, Annemieke $u Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
700    1_
$a Pasmans, Frank $u Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
700    1_
$a Ducatelle, Richard $u Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
700    1_
$a Corander, Jukka $u Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland. Department of Biostatistics, University of Oslo, Oslo, Norway.
700    1_
$a Haesebrouck, Freddy $u Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
773    0_
$w MED00181091 $t The ISME journal $x 1751-7370 $g Roč. 12, č. 1 (2018), s. 77-86
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28885626 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180709 $b ABA008
991    __
$a 20180718102853 $b ABA008
999    __
$a ok $b bmc $g 1316803 $s 1021593
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 12 $c 1 $d 77-86 $e 20170908 $i 1751-7370 $m The ISME journal $n ISME J $x MED00181091
LZP    __
$a Pubmed-20180709

Find record

Citation metrics

Archiving options