-
Je něco špatně v tomto záznamu ?
SAMPA: A free software tool for skin and membrane permeation data analysis
A. Bezrouk, Z. Fiala, L. Kotingová, IS. Krulichová, M. Kopečná, K. Vávrová,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
- MeSH
- kožní absorpce * MeSH
- krysa rodu rattus MeSH
- kůže metabolismus MeSH
- léčivé přípravky metabolismus MeSH
- lidé MeSH
- permeabilita buněčné membrány MeSH
- prasata MeSH
- software * MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Skin and membrane permeation experiments comprise an important step in the development of a transdermal or topical formulation or toxicological risk assessment. The standard method for analyzing these data relies on the linear part of a permeation profile. However, it is difficult to objectively determine when the profile becomes linear, or the experiment duration may be insufficient to reach a maximum or steady state. Here, we present a software tool for Skin And Membrane Permeation data Analysis, SAMPA, that is easy to use and overcomes several of these difficulties. The SAMPA method and software have been validated on in vitro and in vivo permeation data on human, pig and rat skin and model stratum corneum lipid membranes using compounds that range from highly lipophilic polycyclic aromatic hydrocarbons to highly hydrophilic antiviral drug, with and without two permeation enhancers. The SAMPA performance was compared with the standard method using a linear part of the permeation profile and a complex mathematical model. SAMPA is a user-friendly, open-source software tool for analyzing the data obtained from skin and membrane permeation experiments. It runs on a Microsoft Windows platform and is freely available as a Supporting file to this article.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18024796
- 003
- CZ-PrNML
- 005
- 20180718111033.0
- 007
- ta
- 008
- 180709s2017 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.tiv.2017.07.017 $2 doi
- 035 __
- $a (PubMed)28746894
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Bezrouk, Aleš $u Department of Medical Biophysics, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic. Electronic address: bezrouka@lfhk.cuni.cz.
- 245 10
- $a SAMPA: A free software tool for skin and membrane permeation data analysis / $c A. Bezrouk, Z. Fiala, L. Kotingová, IS. Krulichová, M. Kopečná, K. Vávrová,
- 520 9_
- $a Skin and membrane permeation experiments comprise an important step in the development of a transdermal or topical formulation or toxicological risk assessment. The standard method for analyzing these data relies on the linear part of a permeation profile. However, it is difficult to objectively determine when the profile becomes linear, or the experiment duration may be insufficient to reach a maximum or steady state. Here, we present a software tool for Skin And Membrane Permeation data Analysis, SAMPA, that is easy to use and overcomes several of these difficulties. The SAMPA method and software have been validated on in vitro and in vivo permeation data on human, pig and rat skin and model stratum corneum lipid membranes using compounds that range from highly lipophilic polycyclic aromatic hydrocarbons to highly hydrophilic antiviral drug, with and without two permeation enhancers. The SAMPA performance was compared with the standard method using a linear part of the permeation profile and a complex mathematical model. SAMPA is a user-friendly, open-source software tool for analyzing the data obtained from skin and membrane permeation experiments. It runs on a Microsoft Windows platform and is freely available as a Supporting file to this article.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a permeabilita buněčné membrány $7 D002463
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a léčivé přípravky $x metabolismus $7 D004364
- 650 _2
- $a krysa rodu Rattus $7 D051381
- 650 _2
- $a kůže $x metabolismus $7 D012867
- 650 12
- $a kožní absorpce $7 D012869
- 650 12
- $a software $7 D012984
- 650 _2
- $a prasata $7 D013552
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Fiala, Zdeněk $u Department of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
- 700 1_
- $a Kotingová, Lenka $u Department of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
- 700 1_
- $a Krulichová, Iva Selke $u Department of Medical Biophysics, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
- 700 1_
- $a Kopečná, Monika $u Skin Barrier Research Group, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic.
- 700 1_
- $a Vávrová, Kateřina $u Skin Barrier Research Group, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic. Electronic address: katerina.vavrova@faf.cuni.cz.
- 773 0_
- $w MED00004536 $t Toxicology in vitro an international journal published in association with BIBRA $x 1879-3177 $g Roč. 44, č. - (2017), s. 361-371
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28746894 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20180709 $b ABA008
- 991 __
- $a 20180718111333 $b ABA008
- 999 __
- $a ok $b bmc $g 1316927 $s 1021717
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 44 $c - $d 361-371 $e 20170723 $i 1879-3177 $m Toxicology in vitro $n Toxicol In Vitro $x MED00004536
- LZP __
- $a Pubmed-20180709
