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Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study
V. Siersma, H. Thorsen, PE. Holstein, M. Kars, J. Apelqvist, EB. Jude, A. Piaggesi, K. Bakker, M. Edmonds, A. Jirkovská, D. Mauricio, H. Reike, M. Spraul, L. Uccioli, V. Urbancic, K. van Acker, J. van Baal, NC. Schaper,
Language English Country United States
Document type Journal Article, Multicenter Study, Observational Study
NLK
ProQuest Central
from 2003-01-01 to 2 months ago
Nursing & Allied Health Database (ProQuest)
from 2003-01-01 to 2 months ago
Health & Medicine (ProQuest)
from 2003-01-01 to 2 months ago
Family Health Database (ProQuest)
from 2003-01-01 to 2 months ago
- MeSH
- Activities of Daily Living * MeSH
- Depression epidemiology MeSH
- Diabetic Foot epidemiology psychology therapy MeSH
- Wound Healing MeSH
- Cohort Studies MeSH
- Combined Modality Therapy adverse effects MeSH
- Comorbidity MeSH
- Diabetes Complications epidemiology psychology therapy MeSH
- Quality of Life * MeSH
- Middle Aged MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Cost of Illness * MeSH
- Prospective Studies MeSH
- Psychiatric Status Rating Scales MeSH
- Self-Management MeSH
- Aged MeSH
- Anxiety epidemiology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Geographicals
- Europe epidemiology MeSH
AIMS: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment. METHODS: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics. RESULTS: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly. CONCLUSIONS: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers.
Department of Endocrinology University Medical Centre Ljubljana Slovenia
Department of Endocrinology University of Malmö Malmö Sweden
Department of Surgery Twenteborg Ziekenhuis Almelo The Netherlands
Diabetes Centre Institute for Clinical and Experimental Medicine Prague Czech Republic
Diabetes Centre Tameside General Hospital Ashton under Lyne UK
Diabetic Department Kings College Hospital London UK
Innere Abteilung Mariannen Hospital Werl Germany
Mathias Spital Diabetic Department Rheine Germany
Policlinico Tor Vergata Department of Internal Medicine Rome Italy
References provided by Crossref.org
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- $a Siersma, Volkert $u The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. Electronic address: siersma@sund.ku.dk.
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- $a AIMS: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment. METHODS: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics. RESULTS: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly. CONCLUSIONS: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers.
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