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Positive and Negative Signals in Mast Cell Activation
S. Bulfone-Paus, G. Nilsson, P. Draber, U. Blank, F. Levi-Schaffer,
Language English Country England, Great Britain
Document type Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
- MeSH
- Ki-1 Antigen metabolism MeSH
- Cell Degranulation * MeSH
- Immunomodulation MeSH
- Antimicrobial Cationic Peptides metabolism MeSH
- Humans MeSH
- Mast Cells immunology MeSH
- Neuropeptides metabolism MeSH
- Nerve Tissue Proteins metabolism MeSH
- Receptors, IgE metabolism MeSH
- Receptors, Neuropeptide metabolism MeSH
- Receptors, G-Protein-Coupled metabolism MeSH
- Signal Transduction * MeSH
- Ganglia, Spinal metabolism MeSH
- Tetraspanins metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds of activation, these cells release a variety of preformed biologically active products, followed by a wave of mediator synthesis and secretion. Increasing evidence suggests that an intricate network of inhibitory and activating receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to stimuli. Here, we discuss the biological and clinical relevance of negative and positive signaling modalities that control mast cell activation, with an emphasis on novel FcεRI regulators, immunoglobulin E (IgE)-independent pathways [e.g., Mas-related G protein-coupled receptor X2 (MRGPRX2)], tetraspanins, and the CD300 family of inhibitory and activating receptors.
Department of Medical Sciences Uppsala University Uppsala Sweden
INSERM U1149 Centre de Recherche sur l'Inflammation Paris France
References provided by Crossref.org
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