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Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies
P. Kralickova, J. Kuhnova, O. Soucek, P. Vodarek, P. Zak, M. Simkovic, M. Motyckova, L. Smolej, E. Mala, C. Andrys, J. Krejsek, V. Thon,
Language English Country Egypt
Document type Journal Article
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PubMed
29392143
DOI
10.1155/2017/7304658
Knihovny.cz E-resources
- MeSH
- Autoantibodies blood MeSH
- Bacterial Capsules immunology MeSH
- Common Variable Immunodeficiency diagnosis immunology MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Galactosylceramides immunology MeSH
- Immunity, Humoral MeSH
- Immunoglobulin A blood MeSH
- Immunoglobulin G blood MeSH
- Immunoglobulin M blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Pneumococcal Infections diagnosis immunology MeSH
- Prognosis MeSH
- Antibodies, Bacterial blood MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Streptococcus pneumoniae immunology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Humoral deficiencies represent a broad group of disorders. The aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-PCP) and natural anti-galactosyl (anti-Gal) antibodies in (1) patients with chronic lymphocytic leukaemia (CLL), (2) patients with common variable immunodeficiency (CVID), and (3) a healthy population and to explore their diagnostic and prognostic potential. Serum immunoglobulin levels and levels of anti-Gal IgG, IgA, and IgM and anti-PCP IgG and IgG2 were determined in 59 CLL patients, 30 CVID patients, and 67 healthy controls. Levels of IgG, IgA, IgM, anti-Gal IgA, anti-Gal IgM, and anti-PCP IgA were lower in CLL and CVID patients than in healthy controls (p value for all parameters < 0.0001). Decrease in the levels of IgA, IgM, anti-Gal IgA, and anti-PCP IgA was less pronounced in the CLL group than in the CVID group. IgA decline, anti-Gal IgA, anti-PCP IgA, and anti-PCP IgG2 were negatively correlated with CLL stage. We devise the evaluation of anti-Gal antibodies to be a routine test in humoral immunodeficiency diagnostics, even in cases of immunoglobulin substitution therapy. Significant reductions, mainly in anti-Gal IgA, IgM, and anti-PCP IgA levels, may have prognostic importance in CLL patients.
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