• Something wrong with this record ?

Význam echokardiografie a kardiomarkerů v predikci hospitalizační mortality a dlouhodobého rizika mozkových infarktů u pacientů s plicní embolií [Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients]

David Vindiš, Martin Hutyra, Daniel Šaňák, Michal Král, Eva Čecháková, Jana Zapletalová, Simona Littnerová, Tomáš Adam, Jan Přeček, Miloš Táborský

. 2018 ; 60 (2) : 125-133.

Language Czech Country Czech Republic

Document type Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc18037048

Introduction. The aim of prospective study was to evaluate the ability of echocardiography and cardiac biomarkers to predict in-hospital mortality and the risk of brain infarction during a 12-month follow-up period (FUP) with anticoagulation in pulmonary embolism (PE) patients. Methods. Eighty-eight consecutive acute PE patients (39 men, mean age 63 years) were enrolled; 78 underwent baseline echocardiography and brain magnetic resonance imaging (MRI). After a 12-month FUP, 58 underwent brain MRI. In-hospital mortality and the rates of new ischemic brain lesions (IBL) on MRI with clinical ischemic stroke (IS) events were predicted based on echocardiography (patent foramen ovale presence with right-to-left shunt – PFO/RLS; right/left ventricle diameter ratio – RV/LD; tricuspid annulus plane systolic excursion – TAPSE; tricuspid annulus systolic velocity – ST; pulmonary artery systolic pressure – PASP) and biomarkers results (amino-terminal fragment of brain natriuretic peptide – NT-proBNP and cardiac troponin T – cTnT). Results. Our series involved 88 patients, of whom 11 (12.5%) presented high-risk PE, 24 (27.3%) intermediate-high risk PE, 19 (21.6%) intermediate-low risk PE and 34 (38.6%) patients had low risk PE. Nine patients (10.2%) died during hospitalization including high-risk PE [6/9 (66.6%)] and intermediate-high-risk PE [3/24 (12.5%)]. cTnT [odds ratio (OR) 4.3; 95% confidence interval 0.59–31.3, P = 0.014], NT-proBNP (OR 14.2 [1.5–133.4], P = 0.02), RV/LD ≥0.79 (OR 36.6 [4.2–316.4], P = 0.001), TAPSE (OR 0.55 [0.34–0.92, P = 0.022) and PASP ≥51.5 mmHg (OR 33.3 [3.8–292.6], P = 0.022) were predictors of in-hospital mortality. Seventeen patients (19.3%) experienced IS (n = 8) or new IBL (n = 9). On multivariate analysis, PFO/RLS (OR 27.1 [3.0–245.3], P = 0.003) and ST ≤14.5 cm/s (OR 34.1 [CI 3.4–344.0], P = 0.003) were independent predictors of IS and IBL risk. Conclusions. High blood troponin T, NT-proBNP, RV dilatation/systolic dysfunction and pulmonary hypertension predicted in-hospital mortality. PFO/RLS presence and ST were predictors of clinically apparent/silent brain infarction.

Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc18037048
003      
CZ-PrNML
005      
20200217002715.0
007      
ta
008      
181106s2018 xr ad f 000 0|cze||
009      
AR
024    7_
$a 10.1016/j.crvasa.2017.04.003 $2 doi
040    __
$a ABA008 $d ABA008 $e AACR2 $b cze
041    0_
$a cze
044    __
$a xr
100    1_
$a Vindiš, David $7 xx0146879 $u I. interní klinika - kardiologická, Univerzita Palackého a Fakultní nemocnice, Olomouc, Česká republika
245    10
$a Význam echokardiografie a kardiomarkerů v predikci hospitalizační mortality a dlouhodobého rizika mozkových infarktů u pacientů s plicní embolií / $c David Vindiš, Martin Hutyra, Daniel Šaňák, Michal Král, Eva Čecháková, Jana Zapletalová, Simona Littnerová, Tomáš Adam, Jan Přeček, Miloš Táborský
246    31
$a Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients
504    __
$a Literatura
520    9_
$a Introduction. The aim of prospective study was to evaluate the ability of echocardiography and cardiac biomarkers to predict in-hospital mortality and the risk of brain infarction during a 12-month follow-up period (FUP) with anticoagulation in pulmonary embolism (PE) patients. Methods. Eighty-eight consecutive acute PE patients (39 men, mean age 63 years) were enrolled; 78 underwent baseline echocardiography and brain magnetic resonance imaging (MRI). After a 12-month FUP, 58 underwent brain MRI. In-hospital mortality and the rates of new ischemic brain lesions (IBL) on MRI with clinical ischemic stroke (IS) events were predicted based on echocardiography (patent foramen ovale presence with right-to-left shunt – PFO/RLS; right/left ventricle diameter ratio – RV/LD; tricuspid annulus plane systolic excursion – TAPSE; tricuspid annulus systolic velocity – ST; pulmonary artery systolic pressure – PASP) and biomarkers results (amino-terminal fragment of brain natriuretic peptide – NT-proBNP and cardiac troponin T – cTnT). Results. Our series involved 88 patients, of whom 11 (12.5%) presented high-risk PE, 24 (27.3%) intermediate-high risk PE, 19 (21.6%) intermediate-low risk PE and 34 (38.6%) patients had low risk PE. Nine patients (10.2%) died during hospitalization including high-risk PE [6/9 (66.6%)] and intermediate-high-risk PE [3/24 (12.5%)]. cTnT [odds ratio (OR) 4.3; 95% confidence interval 0.59–31.3, P = 0.014], NT-proBNP (OR 14.2 [1.5–133.4], P = 0.02), RV/LD ≥0.79 (OR 36.6 [4.2–316.4], P = 0.001), TAPSE (OR 0.55 [0.34–0.92, P = 0.022) and PASP ≥51.5 mmHg (OR 33.3 [3.8–292.6], P = 0.022) were predictors of in-hospital mortality. Seventeen patients (19.3%) experienced IS (n = 8) or new IBL (n = 9). On multivariate analysis, PFO/RLS (OR 27.1 [3.0–245.3], P = 0.003) and ST ≤14.5 cm/s (OR 34.1 [CI 3.4–344.0], P = 0.003) were independent predictors of IS and IBL risk. Conclusions. High blood troponin T, NT-proBNP, RV dilatation/systolic dysfunction and pulmonary hypertension predicted in-hospital mortality. PFO/RLS presence and ST were predictors of clinically apparent/silent brain infarction.
650    12
$a echokardiografie $x klasifikace $x metody $x přístrojové vybavení $7 D004452
650    12
$a biologické markery $x krev $7 D015415
650    _2
$a riziko $7 D012306
650    _2
$a komorbidita $7 D015897
650    _2
$a prognóza $7 D011379
650    _2
$a mortalita v nemocnicích $7 D017052
650    _2
$a ischemie mozku $x diagnóza $x prevence a kontrola $7 D002545
650    _2
$a mozkový infarkt $x prevence a kontrola $7 D020520
650    _2
$a plicní embolie $x komplikace $x mortalita $7 D011655
650    _2
$a magnetická rezonanční tomografie $7 D008279
650    _2
$a foramen ovale apertum $x diagnóza $7 D054092
650    _2
$a statistika jako téma $7 D013223
650    _2
$a troponin $x krev $7 D014336
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé $7 D006801
650    _2
$a prospektivní studie $7 D011446
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Hutyra, Martin, $d 1974- $7 xx0013232 $u I. interní klinika - kardiologická, Univerzita Palackého a Fakultní nemocnice, Olomouc, Česká republika
700    1_
$a Šaňák, Daniel $7 xx0104413 $u Komplexní cerebrovaskulární centrum, Neurologická klinika, Univerzita Palackého a Fakultní nemocnice, Olomouc, Česká republika
700    1_
$a Král, Michal $7 xx0111643 $u Komplexní cerebrovaskulární centrum, Neurologická klinika, Univerzita Palackého a Fakultní nemocnice, Olomouc, Česká republika
700    1_
$a Čecháková, Eva $7 xx0109141 $u Radiologická klinika, Univerzita Palackého a Fakultní nemocnice, Olomouc, Česká republika
700    1_
$a Zapletalová, Jana $7 xx0111614 $u Ústav lékařské biofyziky, Univerzita palackého, Olomouc, Česká republika
700    1_
$a Littnerová, Simona $7 jo2012694303 $u Institut biostatistiky a analýz Lékařské fakulty Masarykovy univerzity, Brno, Česká republika
700    1_
$a Adam, Tomáš, $d 1965- $7 xx0054162 $u Oddělení klinické biochemie, Fakultní nemocnice, Olomouc, Česká republika
700    1_
$a Přeček, Jan, $d 1985- $7 xx0154445 $u I. interní klinika - kardiologická, Univerzita Palackého a Fakultní nemocnice, Olomouc, Česká republika
700    1_
$a Táborský, Miloš, $d 1962- $7 jn20010310074 $u I. interní klinika - kardiologická, Univerzita Palackého a Fakultní nemocnice, Olomouc, Česká republika
773    0_
$t Cor et Vasa $x 0010-8650 $g Roč. 60, č. 2 (2018), s. 125-133 $w MED00010972
910    __
$a ABA008 $b A 2980 $c 438 $y p $z 0
990    __
$a 20181106115642 $b ABA008
991    __
$a 20200217003115 $b ABA008
999    __
$a ok $b bmc $g 1348858 $s 1034074
BAS    __
$a 3
BMC    __
$a 2018 $b 60 $c 2 $d 125-133 $i 0010-8650 $m Cor et Vasa (Brno) $x MED00010972
LZP    __
$c NLK189 $d 20200217 $a NLK 2018-49/dk

Find record

Citation metrics

Archiving options