-
Something wrong with this record ?
Cell-free nucleic acids in urine as potential biomarkers of kidney disease
Marianna Gyurászová, Alexandra Kovalčíková, Janka Bábíčková, Július Hodosy, Ľubomíra Tóthová
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't, Review
- Keywords
- transrenální DNA, postrenální DNA,
- MeSH
- Biomarkers * MeSH
- Deoxyribonuclease I MeSH
- Extracellular Vesicles MeSH
- Humans MeSH
- DNA, Mitochondrial urine MeSH
- Neoplasms diagnosis MeSH
- Kidney Diseases * diagnosis MeSH
- Cell-Free Nucleic Acids * blood urine MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Kidney and uropoetic system diseases represent a major social, economic and health burden. This is mainly because early diagnosis of kidney dysfunction is currently unavailable, since the current markers are often reliably increased only after advanced progression of the renal diseases. Recently, circulating nucleosomes, DNA and numerous forms of RNA have been detected in human biological fluids, such as plasma, urine, saliva, and breast milk. Although their biological functions remain mostly unknown, they are attractive as potential biomarkers of various diseases. In urine, many of the circulating nucleic acids originate from the cells of the kidney and the urinary tract making these non-invasive and easily obtained new biomarkers in the nephrology or urology. This review focuses on cell free nucleic acids in urine and its potential in human studies. Although, there are some technical and biological limitations, the urinary circulating nucleic acids hold a great potential as new biomarkers of renal diseases.
University Hospital Bratislava Emergency Department Ružinov Bratislava Slovak Republic
University of Bergen Faculty of Medicine Department of Clinical Medicine Bergen Norway
References provided by Crossref.org
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18039966
- 003
- CZ-PrNML
- 005
- 20230914091702.0
- 007
- ta
- 008
- 181211s2018 xr a f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.jab.2018.01.007 $2 doi
- 040 __
- $a ABA008 $d ABA008 $e AACR2 $b cze
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Gyurászová, Marianna $7 xx0230483 $u Comenius University in Bratislava, Faculty of Medicine, Institute of Molecular Biomedicine, Bratislava, Slovak Republic
- 245 10
- $a Cell-free nucleic acids in urine as potential biomarkers of kidney disease / $c Marianna Gyurászová, Alexandra Kovalčíková, Janka Bábíčková, Július Hodosy, Ľubomíra Tóthová
- 504 __
- $a Literatura
- 520 9_
- $a Kidney and uropoetic system diseases represent a major social, economic and health burden. This is mainly because early diagnosis of kidney dysfunction is currently unavailable, since the current markers are often reliably increased only after advanced progression of the renal diseases. Recently, circulating nucleosomes, DNA and numerous forms of RNA have been detected in human biological fluids, such as plasma, urine, saliva, and breast milk. Although their biological functions remain mostly unknown, they are attractive as potential biomarkers of various diseases. In urine, many of the circulating nucleic acids originate from the cells of the kidney and the urinary tract making these non-invasive and easily obtained new biomarkers in the nephrology or urology. This review focuses on cell free nucleic acids in urine and its potential in human studies. Although, there are some technical and biological limitations, the urinary circulating nucleic acids hold a great potential as new biomarkers of renal diseases.
- 650 12
- $a volné cirkulující nukleové kyseliny $x krev $x moč $7 D000073888
- 650 12
- $a nemoci ledvin $x diagnóza $7 D007674
- 650 12
- $a biologické markery $7 D015415
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a deoxyribonukleasa I $7 D003850
- 650 _2
- $a extracelulární vezikuly $7 D000067128
- 650 _2
- $a nádory $x diagnóza $7 D009369
- 650 _2
- $a mitochondriální DNA $x moč $7 D004272
- 653 00
- $a transrenální DNA
- 653 00
- $a postrenální DNA
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Gaál Kovalčíková, Alexandra, $d 1989- $7 xx0306706 $u Comenius University in Bratislava, Faculty of Medicine, Institute of Molecular Biomedicine, Bratislava, Slovak Republic
- 700 1_
- $a Bábíčková, Janka $7 xx0229065 $u Comenius University in Bratislava, Faculty of Medicine, Institute of Molecular Biomedicine, Bratislava, Slovak Republic; University of Bergen, Faculty of Medicine, Department of Clinical Medicine, Bergen, Norway
- 700 1_
- $a Hodosy, Július $7 xx0074118 $u Comenius University in Bratislava, Faculty of Medicine, Institute of Molecular Biomedicine, Bratislava, Slovak Republic; University Hospital Bratislava, Emergency Department Ružinov, Bratislava, Slovak Republic
- 700 1_
- $a Tóthová, Ľubomíra, $d 1984- $7 xx0229262 $u Comenius University in Bratislava, Faculty of Medicine, Institute of Molecular Biomedicine, Bratislava, Slovak Republic
- 773 0_
- $t Journal of applied biomedicine $x 1214-021X $g Roč. 16, č. 3 (2018), s. 157-164 $w MED00012667
- 856 41
- $u https://jab.zsf.jcu.cz/pdfs/jab/2018/03/01.pdf $y plný text volně přístupný
- 910 __
- $a ABA008 $b B 2301 $c 1249 $y 4 $z 0
- 990 __
- $a 20181211090250 $b ABA008
- 991 __
- $a 20230914091657 $b ABA008
- 999 __
- $a ok $b bmc $g 1358040 $s 1037029
- BAS __
- $a 3
- BMC __
- $a 2018 $b 16 $c 3 $d 157-164 $i 1214-021X $m Journal of Applied Biomedicine $x MED00012667
- LZP __
- $c NLK185 $d 20190228 $a NLK 2018-52/dk
