• Je něco špatně v tomto záznamu ?

Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide

T. Rybnikar, M. Senkerik, J. Chladek, J. Chladkova, D. Kalfert, L. Skoloudik,

. 2018 ; 115 (-) : 6-9. [pub] 20180914

Jazyk angličtina Země Irsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19000275

AIM: In patients with primary ciliary dyskinesia (PCD), the release of nitric oxide (NO) is extremely low by epithelia of the nasopharynx and sinuses. Measurement of nasal NO (nNO) is recommended as a screening test for PCD. The study aimed to evaluate if adenoids affects nNO and may deteriorate the performance of the test. METHODS: In 48 nonallergic patients between 5 and 18 years of age with chronic symptoms of nasal obstruction and indications for adenoidectomy, the measurements of nNO by chemiluminescence analyser and nasal patency by active anterior rhinomanometry were performed both before and after adenoidectomy. Adenoidal tissue size was graded during surgery under general anaesthesia using transoral endoscopy. RESULTS: Patients were stratified into groups with adenoids grades 1, 2 and 3 (<1/3, 1/3-2/3 and > 2/3 of the choana and post-nasal space covered by adenoids). Before adenoidectomy, the median of nNO decreased with the increasing grade of adenoids (920, 663, and 491 ppb, P < 0.05). The rhinomanometry results were comparable and showed no correlation with nNO. Seven patients (14.6%) were incorrectly classified to have PCD based on a subthreshold value of the volume flow of nNO (FnNO < 77 nL/min). Following adenoidectomy, nNO of the grade 3 patients increased by 107 ppb (P < 0.05) and no differences were found between groups (P = 0.40). All patients had the postadenoidectomy FnNO >77 nL/min. CONCLUSIONS: nNO and FnNO are reduced in nonallergic children with obstructive adenoids. Adenoid hypertrophy can potentially cause a false positive result of the test for PCD.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19000275
003      
CZ-PrNML
005      
20190121103909.0
007      
ta
008      
190107s2018 ie f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ijporl.2018.09.007 $2 doi
035    __
$a (PubMed)30368395
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ie
100    1_
$a Rybnikar, Tomas $u Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic.
245    10
$a Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide / $c T. Rybnikar, M. Senkerik, J. Chladek, J. Chladkova, D. Kalfert, L. Skoloudik,
520    9_
$a AIM: In patients with primary ciliary dyskinesia (PCD), the release of nitric oxide (NO) is extremely low by epithelia of the nasopharynx and sinuses. Measurement of nasal NO (nNO) is recommended as a screening test for PCD. The study aimed to evaluate if adenoids affects nNO and may deteriorate the performance of the test. METHODS: In 48 nonallergic patients between 5 and 18 years of age with chronic symptoms of nasal obstruction and indications for adenoidectomy, the measurements of nNO by chemiluminescence analyser and nasal patency by active anterior rhinomanometry were performed both before and after adenoidectomy. Adenoidal tissue size was graded during surgery under general anaesthesia using transoral endoscopy. RESULTS: Patients were stratified into groups with adenoids grades 1, 2 and 3 (<1/3, 1/3-2/3 and > 2/3 of the choana and post-nasal space covered by adenoids). Before adenoidectomy, the median of nNO decreased with the increasing grade of adenoids (920, 663, and 491 ppb, P < 0.05). The rhinomanometry results were comparable and showed no correlation with nNO. Seven patients (14.6%) were incorrectly classified to have PCD based on a subthreshold value of the volume flow of nNO (FnNO < 77 nL/min). Following adenoidectomy, nNO of the grade 3 patients increased by 107 ppb (P < 0.05) and no differences were found between groups (P = 0.40). All patients had the postadenoidectomy FnNO >77 nL/min. CONCLUSIONS: nNO and FnNO are reduced in nonallergic children with obstructive adenoids. Adenoid hypertrophy can potentially cause a false positive result of the test for PCD.
650    12
$a adenektomie $7 D000233
650    _2
$a adenoidy $x patologie $x chirurgie $7 D000234
650    _2
$a mladiství $7 D000293
650    _2
$a dechové testy $7 D001944
650    _2
$a dítě $7 D002648
650    _2
$a předškolní dítě $7 D002675
650    _2
$a poruchy ciliární motility $x diagnóza $7 D002925
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a hypertrofie $x komplikace $x patofyziologie $7 D006984
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a plošný screening $7 D008403
650    _2
$a nosní obstrukce $x etiologie $x patofyziologie $7 D015508
650    _2
$a oxid dusnatý $x analýza $7 D009569
650    _2
$a nos $7 D009666
650    _2
$a rinomanometrie $7 D025363
655    _2
$a časopisecké články $7 D016428
700    1_
$a Senkerik, Marian $u Department of Pediatrics and Neonatology, Regional Hospital, Pardubice, Czech Republic.
700    1_
$a Chladek, Jaroslav $u Department of Pharmacology, Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic.
700    1_
$a Chladkova, Jirina $u Department of Pediatrics, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic.
700    1_
$a Kalfert, David $u Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Motol, Charles University, First Faculty of Medicine, Prague, Czech Republic. Electronic address: david.kalfert@fnmotol.cz.
700    1_
$a Skoloudik, Lukas $u Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic.
773    0_
$w MED00002355 $t International journal of pediatric otorhinolaryngology $x 1872-8464 $g Roč. 115, č. - (2018), s. 6-9
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30368395 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190107 $b ABA008
991    __
$a 20190121104128 $b ABA008
999    __
$a ok $b bmc $g 1364390 $s 1038398
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 115 $c - $d 6-9 $e 20180914 $i 1872-8464 $m International journal of pediatric otorhinolaryngology $n Int J Pediatr Otorhinolaryngol $x MED00002355
LZP    __
$a Pubmed-20190107
Zpět

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace