• Je něco špatně v tomto záznamu ?

Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B

K. Brat, M. Plutinsky, K. Hejduk, M. Svoboda, P. Popelkova, J. Zatloukal, E. Volakova, M. Fecaninova, L. Heribanova, V. Koblizek,

. 2018 ; 13 (-) : 1037-1052. [pub] 20180326

Jazyk angličtina Země Nový Zéland

Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19000820

Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients. Kaplan-Meier survival analyses were performed at different levels of respiratory parameters (partial pressure of oxygen in arterial blood [PaO2], partial pressure of arterial carbon dioxide [PaCO2] and greatest decrease of basal peripheral capillary oxygen saturation during 6-minute walking test [6-MWT]). Univariate analyses using the Cox proportional hazard model and multivariate analyses were used to identify risk factors for mortality in hypoxemic and hypercapnic individuals with COPD. Results: All-cause mortality in the cohort at 3 years of prospective follow-up reached 18.4%. Chronic hypoxemia (PaO2 <7.3 kPa), hypercapnia (PaCO2 >7.0 kPa) and oxygen desaturation during the 6-MWT were predictors of long-term mortality in COPD patients with forced expiratory volume in 1 second ≤60% for the overall cohort and for GOLD B category patients. Univariate analyses confirmed the association among decreased oxemia (<7.3 kPa), increased capnemia (>7.0 kPa), oxygen desaturation during 6-MWT and mortality in the studied groups of COPD subjects. Multivariate analysis identified PaO2 <7.3 kPa as a strong independent risk factor for mortality. Conclusion: Survival analyses showed significantly increased all-cause mortality in hypoxemic and hypercapnic GOLD B subjects. More important, PaO2 <7.3 kPa was the strongest risk factor, especially in category B patients. In contrast, the majority of the tested respiratory parameters did not show a difference in mortality in the GOLD category D cohort.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19000820
003      
CZ-PrNML
005      
20200212161854.0
007      
ta
008      
190107s2018 nz f 000 0|eng||
009      
AR
024    7_
$a 10.2147/COPD.S147262 $2 doi
035    __
$a (PubMed)29628761
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a nz
100    1_
$a Brat, Kristian $u Department of Respiratory Diseases, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.
245    10
$a Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B / $c K. Brat, M. Plutinsky, K. Hejduk, M. Svoboda, P. Popelkova, J. Zatloukal, E. Volakova, M. Fecaninova, L. Heribanova, V. Koblizek,
520    9_
$a Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients. Kaplan-Meier survival analyses were performed at different levels of respiratory parameters (partial pressure of oxygen in arterial blood [PaO2], partial pressure of arterial carbon dioxide [PaCO2] and greatest decrease of basal peripheral capillary oxygen saturation during 6-minute walking test [6-MWT]). Univariate analyses using the Cox proportional hazard model and multivariate analyses were used to identify risk factors for mortality in hypoxemic and hypercapnic individuals with COPD. Results: All-cause mortality in the cohort at 3 years of prospective follow-up reached 18.4%. Chronic hypoxemia (PaO2 <7.3 kPa), hypercapnia (PaCO2 >7.0 kPa) and oxygen desaturation during the 6-MWT were predictors of long-term mortality in COPD patients with forced expiratory volume in 1 second ≤60% for the overall cohort and for GOLD B category patients. Univariate analyses confirmed the association among decreased oxemia (<7.3 kPa), increased capnemia (>7.0 kPa), oxygen desaturation during 6-MWT and mortality in the studied groups of COPD subjects. Multivariate analysis identified PaO2 <7.3 kPa as a strong independent risk factor for mortality. Conclusion: Survival analyses showed significantly increased all-cause mortality in hypoxemic and hypercapnic GOLD B subjects. More important, PaO2 <7.3 kPa was the strongest risk factor, especially in category B patients. In contrast, the majority of the tested respiratory parameters did not show a difference in mortality in the GOLD category D cohort.
650    _2
$a senioři $7 D000368
650    _2
$a analýza krevních plynů $7 D001784
650    _2
$a komorbidita $7 D015897
650    _2
$a Česká republika $7 D018153
650    _2
$a databáze faktografické $7 D016208
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a usilovný výdechový objem $7 D005541
650    _2
$a lidé $7 D006801
650    _2
$a hyperkapnie $x diagnóza $x mortalita $x patofyziologie $x terapie $7 D006935
650    _2
$a hypoxie $x diagnóza $x mortalita $x patofyziologie $x terapie $7 D000860
650    _2
$a Kaplanův-Meierův odhad $7 D053208
650    _2
$a plíce $x patofyziologie $7 D008168
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a multivariační analýza $7 D015999
650    _2
$a prediktivní hodnota testů $7 D011237
650    _2
$a prognóza $7 D011379
650    _2
$a proporcionální rizikové modely $7 D016016
650    _2
$a chronická obstrukční plicní nemoc $x diagnóza $x mortalita $x patofyziologie $x terapie $7 D029424
650    12
$a dýchání $7 D012119
650    _2
$a rizikové faktory $7 D012307
650    _2
$a stupeň závažnosti nemoci $7 D012720
650    _2
$a test chůzí $7 D000070857
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Plutinsky, Marek $u Department of Respiratory Diseases, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic.
700    1_
$a Hejduk, Karel $u Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic. $7 xx0227632
700    1_
$a Svoboda, Michal $u Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.
700    1_
$a Popelkova, Patrice $u Pulmonary Department, University Hospital, Ostrava, Czech Republic.
700    1_
$a Zatloukal, Jaromír $7 xx0113000 $u Pulmonary Department, University Hospital, Olomouc, Czech Republic.
700    1_
$a Volakova, Eva $u Pulmonary Department, University Hospital, Olomouc, Czech Republic.
700    1_
$a Fecaninova, Miroslava $u Department of Pneumology, Bulovka Hospital, Prague, Czech Republic.
700    1_
$a Heribanova, Lucie $u Department of Respiratory Medicine, Thomayer Hospital, Prague, Czech Republic.
700    1_
$a Koblizek, Vladimir $u Pulmonary Department, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
773    0_
$w MED00165283 $t International journal of chronic obstructive pulmonary disease $x 1178-2005 $g Roč. 13, č. - (2018), s. 1037-1052
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29628761 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190107 $b ABA008
991    __
$a 20200212162249 $b ABA008
999    __
$a ok $b bmc $g 1364816 $s 1038943
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 13 $c - $d 1037-1052 $e 20180326 $i 1178-2005 $m International journal of COPD $n Int. j. chronic obstr. pulm. dis. $x MED00165283
LZP    __
$a Pubmed-20190107
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace