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Mechanical thrombectomy performs similarly in real world practice: a 2016 nationwide study from the Czech Republic
O. Volny, A. Krajina, S. Belaskova, M. Bar, P. Cimflova, R. Herzig, D. Sanak, A. Tomek, M. Köcher, M. Rocek, R. Padr, F. Cihlar, M. Nevsimalova, L. Jurak, R. Havlicek, M. Kovar, P. Sevcik, V. Rohan, J. Fiksa, BK. Menon, R. Mikulik,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, metaanalýza
- MeSH
- arteria carotis interna diagnostické zobrazování MeSH
- cévní mozková příhoda diagnostické zobrazování epidemiologie terapie MeSH
- infarkt arteria cerebri media diagnostické zobrazování epidemiologie terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- pragmatické klinické studie jako téma metody MeSH
- registrace MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stenty * MeSH
- trombektomie škodlivé účinky metody trendy MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
BACKGROUND: Randomized clinical trials have proven mechanical thrombectomy (MT) to be a highly effective and safe treatment in acute stroke. The purpose of this study was to compare neurothrombectomy data from the Czech Republic (CR) with data from the HERMES meta-analysis. METHODS: Available nationwide data for the CR from 2016 from the Safe Implementation of Treatments in Stroke-Thrombectomy (SITS-TBY) registry for patients with terminal internal carotid artery (ICA) and/or middle cerebral artery (MCA) occlusions were compared with data from HERMES. CR and HERMES patients were comparable in age, sex, and baseline National Institutes of Health Stroke Scale scores. RESULTS: From a total of 1053 MTs performed in the CR, 845 (80%) were reported in the SITS-TBY. From these, 604 (72%) were included in this study. Occlusion locations were as follows (CR vs HERMES): ICA 22% versus 21% (P=0.16), M1 MCA 62% versus 69% (P=0.004), and M2 MCA 16% versus 8% (P<0.0001). Intravenous thrombolysis was given to 76% versus 83% of patients, respectively (P=0.003). Median onset to reperfusion times were comparable: 232 versus 285 min, respectively (P=0.66). A modified Thrombolysis in Cerebral Infarction score of 2b/3 was achieved in 74% (433/584) versus 71% (390/549) of patients, respectively (OR 1.17, 95% CI 0.90-1.5, P=0.24). There was no statistically significant difference in the percentage of parenchymalhematoma type 2 (OR 1.12, 95% CI 0.66-1.90, P=0.68). A modified Rankin Scale score of 0-2 at 3 months was achieved in 48% (184/268) versus 46% (291/633) of patients, respectively (OR 0.92, 95% CI 0.71-1.18, P=0.48). CONCLUSIONS: Data on efficacy, safety, and logistics of MT from the CR were similar to data from the HERMES collaboration.
Department of Neurology Charles University 2nd Medical Faculty Prague Czech Republic
Department of Neurology Hospital Ceske Budejovice Statutory City Czech Republic
Department of Neurology Military University Hospital Prague Canada
Department of Neurology Na Homolce Hospital Prague Czech Republic
Department of Neurology Palacky University Medical School Olomouc Czech Republic
Department of Radiology Masaryk Hospital Usti nad Labem Czech Republic
Neurocentre Regional Hospital Liberec Liberec Czech Republic
Citace poskytuje Crossref.org
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- $a Volny, Ondrej $u Department of Neurology, St Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic. International Clinical Research Centre, Stroke Research Program, St Anne's University Hospital, Brno, Czech Republic.
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- $a Mechanical thrombectomy performs similarly in real world practice: a 2016 nationwide study from the Czech Republic / $c O. Volny, A. Krajina, S. Belaskova, M. Bar, P. Cimflova, R. Herzig, D. Sanak, A. Tomek, M. Köcher, M. Rocek, R. Padr, F. Cihlar, M. Nevsimalova, L. Jurak, R. Havlicek, M. Kovar, P. Sevcik, V. Rohan, J. Fiksa, BK. Menon, R. Mikulik,
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- $a BACKGROUND: Randomized clinical trials have proven mechanical thrombectomy (MT) to be a highly effective and safe treatment in acute stroke. The purpose of this study was to compare neurothrombectomy data from the Czech Republic (CR) with data from the HERMES meta-analysis. METHODS: Available nationwide data for the CR from 2016 from the Safe Implementation of Treatments in Stroke-Thrombectomy (SITS-TBY) registry for patients with terminal internal carotid artery (ICA) and/or middle cerebral artery (MCA) occlusions were compared with data from HERMES. CR and HERMES patients were comparable in age, sex, and baseline National Institutes of Health Stroke Scale scores. RESULTS: From a total of 1053 MTs performed in the CR, 845 (80%) were reported in the SITS-TBY. From these, 604 (72%) were included in this study. Occlusion locations were as follows (CR vs HERMES): ICA 22% versus 21% (P=0.16), M1 MCA 62% versus 69% (P=0.004), and M2 MCA 16% versus 8% (P<0.0001). Intravenous thrombolysis was given to 76% versus 83% of patients, respectively (P=0.003). Median onset to reperfusion times were comparable: 232 versus 285 min, respectively (P=0.66). A modified Thrombolysis in Cerebral Infarction score of 2b/3 was achieved in 74% (433/584) versus 71% (390/549) of patients, respectively (OR 1.17, 95% CI 0.90-1.5, P=0.24). There was no statistically significant difference in the percentage of parenchymalhematoma type 2 (OR 1.12, 95% CI 0.66-1.90, P=0.68). A modified Rankin Scale score of 0-2 at 3 months was achieved in 48% (184/268) versus 46% (291/633) of patients, respectively (OR 0.92, 95% CI 0.71-1.18, P=0.48). CONCLUSIONS: Data on efficacy, safety, and logistics of MT from the CR were similar to data from the HERMES collaboration.
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- $a Krajina, Antonin $u Department of Radiology, Charles University, Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic.
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