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Simultaneous analysis of carbohydrates, polyols and amines in urine samples using chemical ionization gas chromatography with tandem mass spectrometry

R. Kubinec, P. Kotora, V. Ferenczy, J. Blaško, P. Podolec, A. Hengerics Szabó, D. Behúlová, V. Bierhanzl, R. Čabala, S. Stuchlík, W. Filipiak, NM. Thắng,

. 2018 ; 41 (2) : 449-458. [pub] 20171127

Language English Country Germany

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19001122

A simple method for the simultaneous derivatization of carbohydrates, polyols, amines and amino acids using hexamethyldisilazane and N,O-bis(trimethylsilyl)trifluoroacetamide was developed. This method allows the direct derivatization of urine samples without sample pretreatment before derivatization. The method was successfully used for analysis of the selected metabolites in urine samples of healthy individuals and neonates suffering from galactosemia. The limits of detection by positive chemical ionization gas chromatography with tandem mass spectrometry analysis were in the range of 1.0 mgL-1 for mannitol to 4.7 mg/L for glucose.

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$a A simple method for the simultaneous derivatization of carbohydrates, polyols, amines and amino acids using hexamethyldisilazane and N,O-bis(trimethylsilyl)trifluoroacetamide was developed. This method allows the direct derivatization of urine samples without sample pretreatment before derivatization. The method was successfully used for analysis of the selected metabolites in urine samples of healthy individuals and neonates suffering from galactosemia. The limits of detection by positive chemical ionization gas chromatography with tandem mass spectrometry analysis were in the range of 1.0 mgL-1 for mannitol to 4.7 mg/L for glucose.
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$a Kotora, Peter $u Institute of Process Engineering, Faculty of Mechanical Engineering, Slovak University of Technology in Bratislava, Bratislava, Slovakia.
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$a Ferenczy, Viktória $u Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia. Department of Laboratory Medicine, University Children ́s Hospital, Bratislava, Slovakia.
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$a Blaško, Jaroslav $u Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia.
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$a Podolec, Peter $u Axxence Slovakia s.r.o, Bratislava, Slovakia.
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$a Hengerics Szabó, Alexandra $u Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia.
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$a Behúlová, Darina $u Department of Laboratory Medicine, University Children ́s Hospital, Bratislava, Slovakia. $7 xx0330548
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$a Bierhanzl, Václav $u Department of Analytical Chemistry, Faculty of Natural Sciences, Charles University in Prague, Prague, Czech Republic.
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$a Čabala, Radomír $u Department of Analytical Chemistry, Faculty of Natural Sciences, Charles University in Prague, Prague, Czech Republic. Institute of Forensic Medicine and Toxicology, General University Hospital in Prague, Prague, Czech Republic.
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$a Stuchlík, Stanislav, $u Department of Molecular Biology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia. $d 1964- $7 xx0267353
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$a Filipiak, Wojciech $u Department of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz at the Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.
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$a Thắng, Ngô Mạnh $u Department of Physical and Analytical Chemistry, Faculty of Chemical Engineering, HCMC, University of Technology, HCM City, Vietnam.
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