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Structure-Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes
J. Novak, O. Cerny, A. Osickova, I. Linhartova, J. Masin, L. Bumba, P. Sebo, R. Osicka,
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
Grantová podpora
NV16-28126A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
NLK
Directory of Open Access Journals
od 2009
Free Medical Journals
od 2009
PubMed Central
od 2009
Europe PubMed Central
od 2009
ProQuest Central
od 2009-01-01
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od 2009-01-01
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od 2009-01-01
Medline Complete (EBSCOhost)
od 2010-09-01
Health & Medicine (ProQuest)
od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2009
PubMed
28946636
DOI
10.3390/toxins9100300
Knihovny.cz E-zdroje
- MeSH
- adenylátcyklasový toxin chemie MeSH
- alveolární makrofágy cytologie MeSH
- AMP cyklický chemie MeSH
- Bordetella pertussis MeSH
- dendritické buňky cytologie MeSH
- fagocyty chemie MeSH
- kinasa Syk MeSH
- lidé MeSH
- makrofágový antigen 1 MeSH
- neutrofily cytologie MeSH
- proteinové domény MeSH
- signální transdukce * MeSH
- terciární struktura proteinů MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host. CyaA subverts host phagocytic cells by an orchestrated action of its functional domains, where an extremely catalytically active adenylyl cyclase enzyme is delivered into phagocyte cytosol by a pore-forming repeat-in-toxin (RTX) cytolysin moiety. By targeting sentinel cells expressing the complement receptor 3, known as the CD11b/CD18 (αMβ₂) integrin, CyaA compromises the bactericidal functions of host phagocytes and supports infection of host airways by Bordetellae. Here, we review the state of knowledge on structural and functional aspects of CyaA toxin action, placing particular emphasis on signaling mechanisms by which the toxin-produced 3',5'-cyclic adenosine monophosphate (cAMP) subverts the physiology of phagocytic cells.
Citace poskytuje Crossref.org
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