Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Hematological findings in non-treated and gamma-irradiated mice deficient for MIC-1/GDF15

M. Hofer, Z. Hoferová, J. Remšík, M. Nováková, J. Procházková, R. Fedr, J. Kohoutek, L. Dušek, A. Hampl, K. Souček

. 2018 ; 67 (4) : 623-636. [pub] 20180510

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19004015

Grantová podpora
NV15-33999A MZ0 CEP - Centrální evidence projektů
NV15-28628A MZ0 CEP - Centrální evidence projektů

Several members of the TGF-beta family are known to effectively regulate the fate of hematopoietic progenitor cells in a complex and context-dependent manner. Growth differentiation factor-15 (GDF15) is a divergent member of the TGF-beta family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with progression of a variety of pathological conditions. GDF15 is also induced by chemotherapy and irradiation. Very few fundamental studies have been published regarding the effect of GDF15 in hematopoiesis. In this study, we analyzed the hematological status of untreated and gamma-irradiated mice deficient for GDF15 as a result of genetic knock-out (KO), in order to clarify the regulatory role of GDF15 in hematopoiesis. Significant differences between GDF15 KO mice and their pertinent WT controls were found in the parameters of blood monocyte numbers, blood platelet size, and distribution width, as well as in the values of bone marrow granulocyte/macrophage progenitor cells. Different tendencies of some hematological parameters in the GDF15 KO mice in normal conditions and those under exposure of the mice to ionizing radiation were registered. These findings are discussed in the context of the GDF15 gene function and its lack under conditions of radiation-induced damage.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19004015
003      
CZ-PrNML
005      
20201116094315.0
007      
ta
008      
190124s2018 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.933810 $2 doi
035    __
$a (PubMed)29750874
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Hofer, Michal $u Department of Molecular Cytology and Cytometry, Institute of Biophysics of the Czech Academyof Sciences, Brno, Czech Republic $7 xx0074123
245    10
$a Hematological findings in non-treated and gamma-irradiated mice deficient for MIC-1/GDF15 / $c M. Hofer, Z. Hoferová, J. Remšík, M. Nováková, J. Procházková, R. Fedr, J. Kohoutek, L. Dušek, A. Hampl, K. Souček
520    9_
$a Several members of the TGF-beta family are known to effectively regulate the fate of hematopoietic progenitor cells in a complex and context-dependent manner. Growth differentiation factor-15 (GDF15) is a divergent member of the TGF-beta family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with progression of a variety of pathological conditions. GDF15 is also induced by chemotherapy and irradiation. Very few fundamental studies have been published regarding the effect of GDF15 in hematopoiesis. In this study, we analyzed the hematological status of untreated and gamma-irradiated mice deficient for GDF15 as a result of genetic knock-out (KO), in order to clarify the regulatory role of GDF15 in hematopoiesis. Significant differences between GDF15 KO mice and their pertinent WT controls were found in the parameters of blood monocyte numbers, blood platelet size, and distribution width, as well as in the values of bone marrow granulocyte/macrophage progenitor cells. Different tendencies of some hematological parameters in the GDF15 KO mice in normal conditions and those under exposure of the mice to ionizing radiation were registered. These findings are discussed in the context of the GDF15 gene function and its lack under conditions of radiation-induced damage.
650    _2
$a zvířata $7 D000818
650    _2
$a buňky kostní dřeně $x metabolismus $x účinky záření $7 D001854
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a záření gama $x škodlivé účinky $7 D005720
650    _2
$a růstový diferenciační faktor 15 $x nedostatek $x účinky záření $7 D055436
650    _2
$a hematopoéza $x fyziologie $x účinky záření $7 D006410
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myši $7 D051379
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a myši knockoutované $7 D018345
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hoferová, Zuzana $7 xx0074124 $u Department of Molecular Cytology and Cytometry, Institute of Biophysics of the Czech Academyof Sciences, Brno, Czech Republic
700    1_
$a Remšík, Ján. $7 xx0232268 $u Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
700    1_
$a Nováková, Michaela $7 _AN058964 $u Department of Chemistry andToxicology, Veterinary Research Institute, Brno, Czech Republic
700    1_
$a Procházková, J. $7 _AN046502 $u Department of Chemistry andToxicology, Veterinary Research Institute, Brno, Czech Republic
700    1_
$a Fedr, Radek. $7 xx0241223 $u Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
700    1_
$a Kohoutek, Jiří $7 xx0081824 $u Department of Chemistry andToxicology, Veterinary Research Institute, Brno, Czech Republic
700    1_
$a Dušek, Ladislav, $d 1967- $7 mzk2003181727 $u Institute of Biostatistics andAnalyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Hampl, Aleš, $d 1962- $7 ola2002153626 $u International Clinical Research Center,St. Anne's University Hospital, Brno, Czech Republic; Department ofHistology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Souček, Karel $7 xx0140754 $u Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 67, č. 4 (2018), s. 623-636
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29750874 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20190124 $b ABA008
991    __
$a 20201116094315 $b ABA008
999    __
$a ok $b bmc $g 1374804 $s 1042193
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 67 $c 4 $d 623-636 $e 20180510 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
GRA    __
$a NV15-33999A $p MZ0
GRA    __
$a NV15-28628A $p MZ0
LZP    __
$b NLK118 $a Pubmed-20190124

Najít záznam

Citační ukazatele

Možnosti archivace