Variant ALK-fusion positive anaplastic large cell lymphoma (ALCL): A population-based paediatric study of the NHL-BFM study group
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
Hamburger Stiftung zur Foerderung der Krebsbekaempfung
Juli Harnack scholarship of the Foerdergemeinschaft Kinderkrebszentrum Hamburg e.V.
KinderkrebsInitiative Buchholz, Holm-Seppensen
Deutsche Kinderkrebsstiftung
PubMed
38279625
DOI
10.1111/bjh.19308
Knihovny.cz E-zdroje
- Klíčová slova
- ALK positive ALCL, non‐Hodgkin's lymphoma, variant ALK,
- MeSH
- anaplastická lymfomová kináza * genetika analýza MeSH
- anaplastický velkobuněčný lymfom * genetika patologie MeSH
- dítě MeSH
- fúzní onkogenní proteiny genetika MeSH
- jaderné proteiny genetika metabolismus MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- nukleofosmin * MeSH
- předškolní dítě MeSH
- prognóza MeSH
- tropomyosin MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- ALK protein, human MeSH Prohlížeč
- anaplastická lymfomová kináza * MeSH
- fúzní onkogenní proteiny MeSH
- jaderné proteiny MeSH
- NPM1 protein, human MeSH Prohlížeč
- nukleofosmin * MeSH
- TPM3 protein, human MeSH Prohlížeč
- tropomyosin MeSH
Frequency, distribution and prognostic meaning of ALK-partner genes other than NPM1 in ALK-positive anaplastic large-cell lymphoma (ALCL) are unknown. Forty-nine of 316 ALCL diagnosed in the NHL-BFM study group showed no nuclear ALK expression suggestive of a variant ALK-partner; 41 were analysed by genomic capture high-throughput sequencing or specific RT-PCRs. NPM1::ALK was detected in 13 cases. Among the 28 patients with a non-NPM1::ALK-fusion partner, ATIC (n = 8; 29%) and TPM3 (n = 9; 32%) were the most common. Five of eight patients with ATIC::ALK-positive ALCL relapsed, none of nine with TPM3::ALK. Variant ALK-partners are rare and potentially associated with different prognoses.
Bioinformatics Core University Medical Centre Hamburg Eppendorf Hamburg Germany
Department of Pathology Medical University of Vienna Vienna Austria
Department of Pathology University of Wuerzburg Wuerzburg Germany
Faculty of Health Science and Medicine University of Lucerne Lucerne Switzerland
Institute of Human Genetics Ulm University and Ulm University Medical Centre Ulm Germany
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