Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets

M. Vecera, J. Sana, R. Lipina, M. Smrcka, O. Slaby,

. 2018 ; 19 (9) : . [pub] 20180913

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19012379

Grantová podpora
NV15-33158A MZ0 CEP - Centrální evidence projektů
NV15-34553A MZ0 CEP - Centrální evidence projektů

Gliomas are the most common malignancies of the central nervous system. Because of tumor localization and the biological behavior of tumor cells, gliomas are characterized by very poor prognosis. Despite significant efforts that have gone into glioma research in recent years, the therapeutic efficacy of available treatment options is still limited, and only a few clinically usable diagnostic biomarkers are available. More and more studies suggest non-coding RNAs to be promising diagnostic biomarkers and therapeutic targets in many cancers, including gliomas. One of the largest groups of these molecules is long non-coding RNAs (lncRNAs). LncRNAs show promising potential because of their unique tissue expression patterns and regulatory functions in cancer cells. Understanding the role of lncRNAs in gliomas may lead to discovery of the novel molecular mechanisms behind glioma biological features. It may also enable development of new solutions to overcome the greatest obstacles in therapy of glioma patients. In this review, we summarize the current knowledge about lncRNAs and their involvement in the molecular pathology of gliomas. A conclusion follows that these RNAs show great potential to serve as powerful diagnostic, prognostic, and predictive biomarkers as well as therapeutic targets.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19012379
003      
CZ-PrNML
005      
20201116144111.0
007      
ta
008      
190405s2018 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms19092754 $2 doi
035    __
$a (PubMed)30217088
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Vecera, Marek $u Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic. marek.vecera@ceitec.muni.cz.
245    10
$a Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets / $c M. Vecera, J. Sana, R. Lipina, M. Smrcka, O. Slaby,
520    9_
$a Gliomas are the most common malignancies of the central nervous system. Because of tumor localization and the biological behavior of tumor cells, gliomas are characterized by very poor prognosis. Despite significant efforts that have gone into glioma research in recent years, the therapeutic efficacy of available treatment options is still limited, and only a few clinically usable diagnostic biomarkers are available. More and more studies suggest non-coding RNAs to be promising diagnostic biomarkers and therapeutic targets in many cancers, including gliomas. One of the largest groups of these molecules is long non-coding RNAs (lncRNAs). LncRNAs show promising potential because of their unique tissue expression patterns and regulatory functions in cancer cells. Understanding the role of lncRNAs in gliomas may lead to discovery of the novel molecular mechanisms behind glioma biological features. It may also enable development of new solutions to overcome the greatest obstacles in therapy of glioma patients. In this review, we summarize the current knowledge about lncRNAs and their involvement in the molecular pathology of gliomas. A conclusion follows that these RNAs show great potential to serve as powerful diagnostic, prognostic, and predictive biomarkers as well as therapeutic targets.
650    _2
$a zvířata $7 D000818
650    _2
$a nádorové biomarkery $x genetika $7 D014408
650    _2
$a gliom $x genetika $x patologie $7 D005910
650    _2
$a lidé $7 D006801
650    _2
$a molekulární patologie $7 D057089
650    _2
$a prognóza $7 D011379
650    _2
$a RNA dlouhá nekódující $x genetika $7 D062085
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Sana, Jiri $u Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic. sana.jiri@gmail.com. Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic. sana.jiri@gmail.com.
700    1_
$a Lipina, Radim $u Department of Neurosurgery, University Hospital Ostrava, 70852 Ostrava, Czech Republic. radim.lipina@fno.cz.
700    1_
$a Smrcka, Martin $u Department of Neurosurgery, University Hospital Brno, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic. Smrcka.Martin@fnbrno.cz.
700    1_
$a Slaby, Ondrej $u Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic. on.slaby@gmail.com. Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic. on.slaby@gmail.com.
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 19, č. 9 (2018)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30217088 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20201116144109 $b ABA008
999    __
$a ok $b bmc $g 1391689 $s 1050684
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 19 $c 9 $e 20180913 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a NV15-33158A $p MZ0
GRA    __
$a NV15-34553A $p MZ0
LZP    __
$a Pubmed-20190405

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace