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A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases
L. Garzia, N. Kijima, AS. Morrissy, P. De Antonellis, A. Guerreiro-Stucklin, BL. Holgado, X. Wu, X. Wang, M. Parsons, K. Zayne, A. Manno, C. Kuzan-Fischer, C. Nor, LK. Donovan, J. Liu, L. Qin, A. Garancher, KW. Liu, S. Mansouri, B. Luu, YY....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc19012810
Online
Plný text
NLK
Cell Press Free Archives
od 1995-01-01 do Před 1 rokem
Free Medical Journals
od 1995 do Před 1 rokem
Open Access Digital Library
od 1995-01-01
- MeSH
- alografty MeSH
- chemokin CCL2 metabolismus MeSH
- lidé MeSH
- lidské chromozomy, pár 10 genetika MeSH
- meduloblastom krevní zásobení genetika patologie MeSH
- meningeální nádory krevní zásobení sekundární MeSH
- myši SCID MeSH
- nádorové buněčné linie MeSH
- nádorové cirkulující buňky MeSH
- parabióza MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
While the preponderance of morbidity and mortality in medulloblastoma patients are due to metastatic disease, most research focuses on the primary tumor due to a dearth of metastatic tissue samples and model systems. Medulloblastoma metastases are found almost exclusively on the leptomeningeal surface of the brain and spinal cord; dissemination is therefore thought to occur through shedding of primary tumor cells into the cerebrospinal fluid followed by distal re-implantation on the leptomeninges. We present evidence for medulloblastoma circulating tumor cells (CTCs) in therapy-naive patients and demonstrate in vivo, through flank xenografting and parabiosis, that medulloblastoma CTCs can spread through the blood to the leptomeningeal space to form leptomeningeal metastases. Medulloblastoma leptomeningeal metastases express high levels of the chemokine CCL2, and expression of CCL2 in medulloblastoma in vivo is sufficient to drive leptomeningeal dissemination. Hematogenous dissemination of medulloblastoma offers a new opportunity to diagnose and treat lethal disseminated medulloblastoma.
Department of Immunology University of Toronto Toronto ON Canada
Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada
Department of Molecular Oncology British Columbia Cancer Research Centre Vancouver BC Canada
Department of Neurosurgery Huntsman Cancer Institute University of Utah Salt Lake City UT USA
Department of Neurosurgery Stanford University School of Medicine Stanford CA USA
Department of Pathology and Laboratory Medicine University of Calgary Calgary AB Canada
Department of Pediatrics University of California San Diego San Diego CA USA
Developmental and Stem Cell Biology Program The Hospital for Sick Children Toronto ON Canada
Division of Haematology Oncology The Hospital for Sick Children Toronto ON Canada
Division of Hematology Oncology McGill University Montreal QC Canada
Division of Neuro Oncology Massachusetts General Hospital Boston MA USA
Division of Neurosurgery The Hospital for Sick Children Toronto ON Canada
Division of Pathology The Hospital for Sick Children Toronto ON Canada
Fondazione IRCCS Istituto Nazionale Tumori Milan Italy
Lunenfeld Tanenbaum Research Institute Mount Sinai Hospital Toronto ON M5G 1X5 Canada
Toronto General Research Institute University Health Network Toronto ON Canada
Citace poskytuje Crossref.org
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