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Stable isotope compounds - production, detection, and application
V. Zachleder, M. Vítová, M. Hlavová, Š. Moudříková, P. Mojzeš, H. Heumann, JR. Becher, K. Bišová,
Biotechnology advances.
2018 ;
36 (3) :
784-797.
[pub] 20180119
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Persistent link
https://www.medvik.cz/link/bmc19012899
- MeSH
- Biotechnology methods MeSH
- Chlorophyta growth & development metabolism MeSH
- Deuterium administration & dosage adverse effects analysis MeSH
- Mass Spectrometry methods MeSH
- Isotope Labeling methods MeSH
- Isotopes analysis chemistry MeSH
- Magnetic Resonance Spectroscopy MeSH
- Drug Design * MeSH
- Spectrum Analysis, Raman methods MeSH
- Plants drug effects MeSH
- Mammals MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Stable isotopes are used in wide fields of application from natural tracers in biology, geology and archeology through studies of metabolic fluxes to their application as tracers in quantitative proteomics and structural biology. We review the use of stable isotopes of biogenic elements (H, C, N, O, S, Mg, Se) with the emphasis on hydrogen and its heavy isotope deuterium. We will discuss the limitations of enriching various compounds in stable isotopes when produced in living organisms. Finally, we overview methods for measuring stable isotopes, focusing on methods for detection in single cells in situ and their exploitation in modern biotechnologies.
References provided by Crossref.org
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