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Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

RC. Keynejad, H. Marková, K. Šiffelová, N. Kumar, K. Vlček, J. Laczó, EM. Migo, J. Hort, MD. Kopelman,

. 2018 ; 25 (2) : 277-289. [pub] 20170228

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19013151

AIMS: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI). METHODS: We recruited aMCI patients with (n = 21) and without (n = 21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n = 22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests. RESULTS: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI. CONCLUSIONS: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess "pure" aMCI, we may underestimate patients' navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.

Citace poskytuje Crossref.org

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$a AIMS: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI). METHODS: We recruited aMCI patients with (n = 21) and without (n = 21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n = 22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests. RESULTS: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI. CONCLUSIONS: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess "pure" aMCI, we may underestimate patients' navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.
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$a Marková, Hana $u b Memory Clinic, Department of Neurology , Charles University and Motol University Hospital , Prague , Czech Republic. c International Clinical Research Center , St Anne's University Hospital Brno , Brno , Czech Republic.
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$a Šiffelová, Kamila $u b Memory Clinic, Department of Neurology , Charles University and Motol University Hospital , Prague , Czech Republic.
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$a Kumar, Naveen $u a Psychology and Neuroscience , Institute of Psychiatry, King's College London , London , UK.
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$a Vlček, Kamil $u d Department of Neurophysiology of Memory , Institute of Physiology, Academy of Sciences of the Czech Republic , Prague , Czech Republic.
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$a Laczó, Jan $u b Memory Clinic, Department of Neurology , Charles University and Motol University Hospital , Prague , Czech Republic. c International Clinical Research Center , St Anne's University Hospital Brno , Brno , Czech Republic.
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$a Migo, Ellen M $u a Psychology and Neuroscience , Institute of Psychiatry, King's College London , London , UK.
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$a Hort, Jakub $u b Memory Clinic, Department of Neurology , Charles University and Motol University Hospital , Prague , Czech Republic. c International Clinical Research Center , St Anne's University Hospital Brno , Brno , Czech Republic.
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