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Relapse in schizophrenia: Definitively not a bolt from the blue
F. Spaniel, E. Bakstein, J. Anyz, J. Hlinka, T. Sieger, J. Hrdlicka, N. Görnerová, C. Höschl,
Jazyk angličtina Země Irsko
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- MeSH
- chronická nemoc MeSH
- dospělí MeSH
- lidé MeSH
- prodromální symptomy MeSH
- průzkumy a dotazníky MeSH
- recidiva MeSH
- retrospektivní studie MeSH
- schizofrenie (psychologie) * MeSH
- schizofrenie diagnóza prevence a kontrola MeSH
- sekundární prevence MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Detailed study of the period before schizophrenic relapse when early warning signs (EWS) are present is crucial to effective pre-emptive strategies. To investigate the temporal properties of EWS self-reported weekly via a telemedicine system. EWS history was obtained for 61 relapses resulting in hospitalization involving 51 patients with schizophrenia. Up to 20 weeks of EWS history per case were evaluated using a non-parametric bootstrap test and generalized mixed-effects model to test the significance and homogeneity of the findings. A statistically significant increase in EWS sum score was detectable 5 weeks before hospitalization. However, analysis of EWS dynamics revealed a gradual, monotonic increase in EWS score across during the 8 weeks before a relapse. The findings-in contrast to earlier studies-suggest that relapse is preceded by a lengthy period during which pathophysiological processes unfold; these changes are reflected in subjective EWS.
3rd Faculty of Medicine Charles University Prague Czech Republic
Institute of Computer Science The Czech Academy of Sciences Prague Czech Republic
Citace poskytuje Crossref.org
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- $a Spaniel, Filip $u National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: filip.spaniel@nudz.cz.
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- $a Detailed study of the period before schizophrenic relapse when early warning signs (EWS) are present is crucial to effective pre-emptive strategies. To investigate the temporal properties of EWS self-reported weekly via a telemedicine system. EWS history was obtained for 61 relapses resulting in hospitalization involving 51 patients with schizophrenia. Up to 20 weeks of EWS history per case were evaluated using a non-parametric bootstrap test and generalized mixed-effects model to test the significance and homogeneity of the findings. A statistically significant increase in EWS sum score was detectable 5 weeks before hospitalization. However, analysis of EWS dynamics revealed a gradual, monotonic increase in EWS score across during the 8 weeks before a relapse. The findings-in contrast to earlier studies-suggest that relapse is preceded by a lengthy period during which pathophysiological processes unfold; these changes are reflected in subjective EWS.
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- $a Hrdlicka, Jan $u National Institute of Mental Health, Klecany, Czech Republic.
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