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Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
J. Wirbel, PT. Pyl, E. Kartal, K. Zych, A. Kashani, A. Milanese, JS. Fleck, AY. Voigt, A. Palleja, R. Ponnudurai, S. Sunagawa, LP. Coelho, P. Schrotz-King, E. Vogtmann, N. Habermann, E. Niméus, AM. Thomas, P. Manghi, S. Gandini, D. Serrano, S....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, metaanalýza, Research Support, N.I.H., Extramural
Grantová podpora
U01 CA206110
NIH HHS - United States
P30 CA042014
NIH HHS - United States
R01 CA189184
NIH HHS - United States
R01 CA189184
NCI NIH HHS - United States
U01 CA206110
NCI NIH HHS - United States
R01 CA207371
NIH HHS - United States
R01 CA207371
NCI NIH HHS - United States
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- adenom genetika mikrobiologie MeSH
- biologické modely MeSH
- databáze genetické MeSH
- druhová specificita MeSH
- feces mikrobiologie MeSH
- kohortové studie MeSH
- kolorektální nádory genetika mikrobiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- metagenom * MeSH
- nádorové biomarkery metabolismus MeSH
- reprodukovatelnost výsledků MeSH
- senioři MeSH
- střevní mikroflóra genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- Research Support, N.I.H., Extramural MeSH
Association studies have linked microbiome alterations with many human diseases. However, they have not always reported consistent results, thereby necessitating cross-study comparisons. Here, a meta-analysis of eight geographically and technically diverse fecal shotgun metagenomic studies of colorectal cancer (CRC, n = 768), which was controlled for several confounders, identified a core set of 29 species significantly enriched in CRC metagenomes (false discovery rate (FDR) < 1 × 10-5). CRC signatures derived from single studies maintained their accuracy in other studies. By training on multiple studies, we improved detection accuracy and disease specificity for CRC. Functional analysis of CRC metagenomes revealed enriched protein and mucin catabolism genes and depleted carbohydrate degradation genes. Moreover, we inferred elevated production of secondary bile acids from CRC metagenomes, suggesting a metabolic link between cancer-associated gut microbes and a fat- and meat-rich diet. Through extensive validations, this meta-analysis firmly establishes globally generalizable, predictive taxonomic and functional microbiome CRC signatures as a basis for future diagnostics.
Department CIBIO University of Trento Trento Italy
Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA
Division of Cancer Genomics National Cancer Center Research Institute Tokyo Japan
Genome Biology Unit European Molecular Biology Laboratory Heidelberg Germany
IEO European Institute of Oncology IRCCS Milan Italy
School of Life Science and Technology Tokyo Institute of Technology Tokyo Japan
Structural and Computational Biology Unit European Molecular Biology Laboratory Heidelberg Germany
Citace poskytuje Crossref.org
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