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Controlling metastatic cancer: the role of phytochemicals in cell signaling
A. Kapinova, P. Kubatka, A. Liskova, D. Baranenko, P. Kruzliak, M. Matta, D. Büsselberg, B. Malicherova, A. Zulli, TK. Kwon, E. Jezkova, D. Blahutova, P. Zubor, J. Danko,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, přehledy
Grantová podpora
VEGA 1/0136/19
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
VEGA 1/0124/17
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2003-04-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 1997-01-01 do Před 1 rokem
ROAD: Directory of Open Access Scholarly Resources
od 1997
- MeSH
- biologické markery MeSH
- chemoprofylaxe MeSH
- chemorezistence účinky léků MeSH
- epitelo-mezenchymální tranzice účinky léků MeSH
- fytogenní protinádorové látky chemie farmakologie terapeutické užití MeSH
- fytonutrienty chemie farmakologie terapeutické užití MeSH
- invazivní růst nádoru MeSH
- klinická studie jako téma MeSH
- lidé MeSH
- metastázy nádorů MeSH
- nádorové mikroprostředí MeSH
- nádory etiologie metabolismus patologie terapie MeSH
- preklinické hodnocení léčiv MeSH
- protokoly protinádorové kombinované chemoterapie škodlivé účinky terapeutické užití MeSH
- regulace genové exprese u nádorů MeSH
- signální transdukce účinky léků MeSH
- staging nádorů MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
PURPOSE: Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. RESULTS: Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds. CONCLUSIONS: Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.
Department of Immunology School of Medicine Keimyung University Daegu South Korea
Institute for Health and Sport Victoria University Melbourne Australia
Citace poskytuje Crossref.org
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