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Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation
Z. Stejskalova, Z. Rohan, R. Rusina, A. Tesar, J. Kukal, GG. Kovacs, A. Bartos, R. Matej,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
VFN64165
Ministerstvo Zdravotnictví Ceské Republiky
TN64190
Thomayer hospital
Q27/LF1
Univerzita Karlova v Praze
Q28/LF1
Univerzita Karlova v Praze
Q35/LF3
Univerzita Karlova v Praze
GAUK 113115
Univerzita Karlova v Praze
NPU I LO1611
Ministerstvo Školství, Mládeže a Tělovýchovy
AVASTipendium
Czech Alzheimer Foundation and AVAST!
NLK
BioMedCentral
od 2001-12-01
BioMedCentral Open Access
od 2001
Directory of Open Access Journals
od 2001
Free Medical Journals
od 2001
PubMed Central
od 2001
Europe PubMed Central
od 2001
ProQuest Central
od 2009-01-01
Open Access Digital Library
od 2001-01-01
Open Access Digital Library
od 2001-01-01
Open Access Digital Library
od 2001-01-01
Medline Complete (EBSCOhost)
od 2001-12-18
Health & Medicine (ProQuest)
od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2001
Springer Nature OA/Free Journals
od 2001-12-01
- MeSH
- imunohistochemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mozková kůra patologie MeSH
- parkinsonské poruchy diagnóza patologie MeSH
- pohybové poruchy diagnóza patologie MeSH
- progresivní supranukleární obrna diagnóza patologie MeSH
- proteiny tau metabolismus MeSH
- pyramidové dráhy patologie MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: We aimed to produce a detailed neuropathological analysis of pyramidal motor system pathology and provide its clinical pathological correlation in cases with definite progressive supranuclear palsy (PSP). METHODS: Pyramidal motor system pathologies were analyzed in 18 cases with neuropathologically confirmed PSP. Based on a retrospective clinical analysis, cases were subtyped according to Movement Disorder Society criteria for clinical diagnosis of PSP as probable, possible or suggestive of PSP with Richardson's syndrome (n = 10), PSP with predominant corticobasal syndrome (n = 3), PSP with predominant parkinsonism (n = 3), PSP with predominant speech/language disorder (n = 1), and PSP with progressive gait freezing (n = 1). Clinical manifestations of motor neuron involvement (pseudobulbar or bulbar signs and spasticity) were retrospectively assessed semiquantitatively. Neuropathologically, hyperphosphorylated tau-related pyramidal motor system neuronal, neuritic, and glial pathology using anti-tau AT8 clone immunohistochemistry, was also evaluated. RESULTS: Clinical manifestations of pyramidal motor system involvement were found in patients with different PSP subtypes. A statistically significant higher load of tau pathology was found in the pyramidal system in PSP-Richardson's syndrome compared to other PSP subtypes (p = 0.016); however, there was no significant correlation between pyramidal system tau pathology and related motor clinical symptoms. CONCLUSIONS: Tau pathology in the spinal cord and pyramidal motor system structures is very common in progressive supranuclear palsy and may neuropathologically supplement the distinction between classic Richardson's syndrome from other progressive supranuclear palsy subtypes.
Citace poskytuje Crossref.org
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- $a Stejskalova, Zuzana $u Department of Pathology and Molecular Medicine Third Faculty of Medicine, Charles University and Thomayer Hospital, Videnska 800, 14059, Prague 4 - Krc, Czech Republic. Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Department of Pathology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
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- $a Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation / $c Z. Stejskalova, Z. Rohan, R. Rusina, A. Tesar, J. Kukal, GG. Kovacs, A. Bartos, R. Matej,
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- $a BACKGROUND: We aimed to produce a detailed neuropathological analysis of pyramidal motor system pathology and provide its clinical pathological correlation in cases with definite progressive supranuclear palsy (PSP). METHODS: Pyramidal motor system pathologies were analyzed in 18 cases with neuropathologically confirmed PSP. Based on a retrospective clinical analysis, cases were subtyped according to Movement Disorder Society criteria for clinical diagnosis of PSP as probable, possible or suggestive of PSP with Richardson's syndrome (n = 10), PSP with predominant corticobasal syndrome (n = 3), PSP with predominant parkinsonism (n = 3), PSP with predominant speech/language disorder (n = 1), and PSP with progressive gait freezing (n = 1). Clinical manifestations of motor neuron involvement (pseudobulbar or bulbar signs and spasticity) were retrospectively assessed semiquantitatively. Neuropathologically, hyperphosphorylated tau-related pyramidal motor system neuronal, neuritic, and glial pathology using anti-tau AT8 clone immunohistochemistry, was also evaluated. RESULTS: Clinical manifestations of pyramidal motor system involvement were found in patients with different PSP subtypes. A statistically significant higher load of tau pathology was found in the pyramidal system in PSP-Richardson's syndrome compared to other PSP subtypes (p = 0.016); however, there was no significant correlation between pyramidal system tau pathology and related motor clinical symptoms. CONCLUSIONS: Tau pathology in the spinal cord and pyramidal motor system structures is very common in progressive supranuclear palsy and may neuropathologically supplement the distinction between classic Richardson's syndrome from other progressive supranuclear palsy subtypes.
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- $a Matej, Radoslav $u Department of Pathology and Molecular Medicine Third Faculty of Medicine, Charles University and Thomayer Hospital, Videnska 800, 14059, Prague 4 - Krc, Czech Republic. Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Department of Pathology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic. Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
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