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Experiences in the treatment of refractory chylothorax associated with lymphoproliferative disorders

J. Pospiskova, L. Smolej, D. Belada, M. Simkovic, M. Motyckova, A. Sykorova, P. Stepankova, P. Zak,

. 2019 ; 14 (1) : 9. [pub] 20190109

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Grant support
PROGRES Q40/08 Univerzita Karlova v Praze - International

BACKGROUND: Chylothorax is a rare condition which can be associated with malignant lymphoproliferative disorders (LPDs). We retrospectively analyzed the results of the conservative treatment of 10 patients with persistent non-traumatic malignant chylothorax. RESULTS: Conservative treatment lead to a decline of chylothorax after mean of 66 days and consisted of the treatment of the underlying disease and of simultaneous long-term supportive care (drainage of the thoracic cavity, dietary measures and nutrition management). In most cases (80%), chylothorax disappeared only after a successful therapeutic response of the underlying disease. Low-dose radiotherapy had very good effects in two patients. CONCLUSION: Conservative treatment of malignant chylothorax can be considered a suitable method. Based on our results, successful treatment of the lymphoproliferative disorder seems to be a very important factor for the disappearance of chylothorax.

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$a Motyckova, Monika $u 4th Department of Internal Medicine - Hematology, University Hospital, Sokolska Street 581, 5005, Hradec Kralove, Czech Republic. Faculty of Medicine in Hradec Králové, Charles University Prague, Hradec Kralove, Czech Republic.
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