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Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics
M. Šoltys, D. Zůza, T. Boleslavská, S. Machač Akhlasová, M. Balouch, P. Kovačík, J. Beránek, N. Škalko-Basnet, GE. Flaten, F. Štěpánek
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- kinetika MeSH
- nosiče léků * MeSH
- oxid křemičitý * MeSH
- poréznost MeSH
- rozpouštědla MeSH
- rozpustnost MeSH
- uvolňování léčiv MeSH
- Publikační typ
- časopisecké články MeSH
The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted mass fraction of the API. At present, there is no established methodology for the rational selection of these parameters. In the present work, we report a systematic comparison of four well-characterised silica carriers and seven APIs loaded by the same solvent evaporation method. In each case, we find the maximum amorphization capacity by x-ray powder diffraction analysis and measure the in vitro drug release kinetics. For a selected case, we also demonstrate the potential for bioavailability enhancement by a permeation essay.
Citace poskytuje Crossref.org
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- $a Šoltys, Marek $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic; Department of Pharmacy, UiT The Arctic University of Norway, Norway
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- $a Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics / $c M. Šoltys, D. Zůza, T. Boleslavská, S. Machač Akhlasová, M. Balouch, P. Kovačík, J. Beránek, N. Škalko-Basnet, GE. Flaten, F. Štěpánek
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- $a The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted mass fraction of the API. At present, there is no established methodology for the rational selection of these parameters. In the present work, we report a systematic comparison of four well-characterised silica carriers and seven APIs loaded by the same solvent evaporation method. In each case, we find the maximum amorphization capacity by x-ray powder diffraction analysis and measure the in vitro drug release kinetics. For a selected case, we also demonstrate the potential for bioavailability enhancement by a permeation essay.
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- $a Zůza, David $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
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- $a Machač Akhlasová, Sarah $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic
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- $a Balouch, Martin $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic
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- $a Škalko-Basnet, Nataša $u Department of Pharmacy, UiT The Arctic University of Norway, Norway
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- $a Štěpánek, František $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. Electronic address: Frantisek.Stepanek@vscht.cz
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