• Je něco špatně v tomto záznamu ?

Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics

M. Šoltys, D. Zůza, T. Boleslavská, S. Machač Akhlasová, M. Balouch, P. Kovačík, J. Beránek, N. Škalko-Basnet, GE. Flaten, F. Štěpánek

. 2021 ; 607 (-) : 120982. [pub] 20210808

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21024941

The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted mass fraction of the API. At present, there is no established methodology for the rational selection of these parameters. In the present work, we report a systematic comparison of four well-characterised silica carriers and seven APIs loaded by the same solvent evaporation method. In each case, we find the maximum amorphization capacity by x-ray powder diffraction analysis and measure the in vitro drug release kinetics. For a selected case, we also demonstrate the potential for bioavailability enhancement by a permeation essay.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21024941
003      
CZ-PrNML
005      
20211026134249.0
007      
ta
008      
211013s2021 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ijpharm.2021.120982 $2 doi
035    __
$a (PubMed)34371148
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Šoltys, Marek $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic; Department of Pharmacy, UiT The Arctic University of Norway, Norway
245    10
$a Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics / $c M. Šoltys, D. Zůza, T. Boleslavská, S. Machač Akhlasová, M. Balouch, P. Kovačík, J. Beránek, N. Škalko-Basnet, GE. Flaten, F. Štěpánek
520    9_
$a The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted mass fraction of the API. At present, there is no established methodology for the rational selection of these parameters. In the present work, we report a systematic comparison of four well-characterised silica carriers and seven APIs loaded by the same solvent evaporation method. In each case, we find the maximum amorphization capacity by x-ray powder diffraction analysis and measure the in vitro drug release kinetics. For a selected case, we also demonstrate the potential for bioavailability enhancement by a permeation essay.
650    12
$a nosiče léků $7 D004337
650    _2
$a uvolňování léčiv $7 D065546
650    _2
$a kinetika $7 D007700
650    _2
$a poréznost $7 D016062
650    12
$a oxid křemičitý $7 D012822
650    _2
$a rozpustnost $7 D012995
650    _2
$a rozpouštědla $7 D012997
655    _2
$a časopisecké články $7 D016428
700    1_
$a Zůza, David $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
700    1_
$a Boleslavská, Tereza $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic
700    1_
$a Machač Akhlasová, Sarah $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic
700    1_
$a Balouch, Martin $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic
700    1_
$a Kovačík, Pavel $u Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic
700    1_
$a Beránek, Josef $u Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic
700    1_
$a Škalko-Basnet, Nataša $u Department of Pharmacy, UiT The Arctic University of Norway, Norway
700    1_
$a Flaten, Gøril Eide $u Department of Pharmacy, UiT The Arctic University of Norway, Norway
700    1_
$a Štěpánek, František $u Department of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. Electronic address: Frantisek.Stepanek@vscht.cz
773    0_
$w MED00002359 $t International journal of pharmaceutics $x 1873-3476 $g Roč. 607, č. - (2021), s. 120982
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34371148 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20211013 $b ABA008
991    __
$a 20211026134255 $b ABA008
999    __
$a ok $b bmc $g 1714128 $s 1145448
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 607 $c - $d 120982 $e 20210808 $i 1873-3476 $m International journal of pharmaceutics $n Int. j. pharm. $x MED00002359
LZP    __
$a Pubmed-20211013

Najít záznam

Citační ukazatele

Nahrávání dat ...

    Možnosti archivace