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Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues

E. Heude, M. Tesarova, EM. Sefton, E. Jullian, N. Adachi, A. Grimaldi, T. Zikmund, J. Kaiser, G. Kardon, RG. Kelly, S. Tajbakhsh,

. 2018 ; 7 (-) : . [pub] 20181119

Language English Country England, Great Britain

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc19028068

In vertebrates, head and trunk muscles develop from different mesodermal populations and are regulated by distinct genetic networks. Neck muscles at the head-trunk interface remain poorly defined due to their complex morphogenesis and dual mesodermal origins. Here, we use genetically modified mice to establish a 3D model that integrates regulatory genes, cell populations and morphogenetic events that define this transition zone. We show that the evolutionary conserved cucullaris-derived muscles originate from posterior cardiopharyngeal mesoderm, not lateral plate mesoderm, and we define new boundaries for neural crest and mesodermal contributions to neck connective tissue. Furthermore, lineage studies and functional analysis of Tbx1- and Pax3-null mice reveal a unique developmental program for somitic neck muscles that is distinct from that of somitic trunk muscles. Our findings unveil the embryological and developmental requirements underlying tetrapod neck myogenesis and provide a blueprint to investigate how muscle subsets are selectively affected in some human myopathies.

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$a In vertebrates, head and trunk muscles develop from different mesodermal populations and are regulated by distinct genetic networks. Neck muscles at the head-trunk interface remain poorly defined due to their complex morphogenesis and dual mesodermal origins. Here, we use genetically modified mice to establish a 3D model that integrates regulatory genes, cell populations and morphogenetic events that define this transition zone. We show that the evolutionary conserved cucullaris-derived muscles originate from posterior cardiopharyngeal mesoderm, not lateral plate mesoderm, and we define new boundaries for neural crest and mesodermal contributions to neck connective tissue. Furthermore, lineage studies and functional analysis of Tbx1- and Pax3-null mice reveal a unique developmental program for somitic neck muscles that is distinct from that of somitic trunk muscles. Our findings unveil the embryological and developmental requirements underlying tetrapod neck myogenesis and provide a blueprint to investigate how muscle subsets are selectively affected in some human myopathies.
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$a Tesarova, Marketa $u Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
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$a Sefton, Elizabeth M $u Department of Human Genetics, University of Utah, Salt Lake City, United States.
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$a Jullian, Estelle $u Aix-Marseille Université, CNRS UMR 7288, IBDM, Marseille, France.
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$a Adachi, Noritaka $u Aix-Marseille Université, CNRS UMR 7288, IBDM, Marseille, France.
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$a Grimaldi, Alexandre $u Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France. CNRS UMR 3738, Paris, France.
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$a Zikmund, Tomas $u Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
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$a Kaiser, Jozef $u Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
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$a Kardon, Gabrielle $u Department of Human Genetics, University of Utah, Salt Lake City, United States.
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$a Kelly, Robert G $u Aix-Marseille Université, CNRS UMR 7288, IBDM, Marseille, France.
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$a Tajbakhsh, Shahragim $u Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France. CNRS UMR 3738, Paris, France.
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