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Resistive pulse sensing as particle counting and sizing method in microfluidic systems: Designs and applications review
T. Vaclavek, J. Prikryl, F. Foret,
Language English Country Germany
Document type Journal Article, Review
Grant support
16-09283Y
Czech Science Foundation
18-03367Y
Czech Science Foundation
P206/12/G014
Czech Science Foundation
RVO: 68081715
Czech Academy of Sciences
- MeSH
- Single-Cell Analysis instrumentation MeSH
- Equipment Design MeSH
- Electrodes MeSH
- Humans MeSH
- Microfluidic Analytical Techniques instrumentation MeSH
- Particle Size MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Resistive pulse sensing is a well-known and established method for counting and sizing particles in ionic solutions. Throughout its development the technique has been expanded from detection of biological cells to counting nanoparticles and viruses, and even registering individual molecules, e.g., nucleotides in nucleic acids. This technique combined with microfluidic or nanofluidic systems shows great potential for various bioanalytical applications, which were hardly possible before microfabrication gained the present broad adoption. In this review, we provide a comprehensive overview of microfluidic designs along with electrode arrangements with emphasis on applications focusing on bioanalysis and analysis of single cells that were reported within the past five years.
References provided by Crossref.org
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