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Markers of Atherosclerosis: Part 2 - Genetic and Imaging Markers
M. Tibaut, M. Caprnda, P. Kubatka, A. Sinkovič, V. Valentova, S. Filipova, K. Gazdikova, L. Gaspar, I. Mozos, EE. Egom, L. Rodrigo, P. Kruzliak, D. Petrovic,
Jazyk angličtina Země Austrálie
Typ dokumentu časopisecké články, přehledy
- MeSH
- ateroskleróza * krev diagnóza genetika MeSH
- biologické markery krev MeSH
- diagnostické zobrazování metody MeSH
- genetické markery * MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
This is Part 2 of a two-part review summarising current knowledge on biomarkers of atherosclerosis. Part 1 addressed serological biomarkers. Here, in part 2 we address genetic and imaging markers, and other developments in predicting risk. Further improvements in risk stratification are expected with the addition of genetic risk scores. In addition to single nucleotide polymorphisms (SNPs), recent advances in epigenetics offer DNA methylation profiles, histone chemical modifications, and micro-RNAs as other promising indicators of atherosclerosis. Imaging biomarkers are better studied and already have a higher degree of clinical applicability in cardiovascular (CV) event prediction and detection of preclinical atherosclerosis. With new methodologies, such as proteomics and metabolomics, discoveries of new clinically applicable biomarkers are expected.
1st Department of Internal Medicine Faculty of Medicine Comenius University Bratislava Slovakia
Department of Functional Sciences Victor Babes University of Medicine and Pharmacy Timisoara Romania
Department of General Medicine Faculty of Medicine Slovak Medical University Bratislava Slovakia
Department of Internal Medicine Brothers of Mercy Hospital Brno Czech Republic
Faculty of Medicine University of Oviedo Central University Hospital of Asturias Oviedo Spain
Faculty of Pharmacy University of Ljubljana Ljubljana Slovenia
General Hospital Murska Sobota Murska Sobota Slovenia
Independent Researcher Mosjøen Norway
Institute of Histology and Embryology Faculty of Medicine University of Ljubljana Ljubljana Slovenia
Jewish General Hospital and Lady Davis Institute for Medical Research Montreal Canada
Citace poskytuje Crossref.org
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- $a This is Part 2 of a two-part review summarising current knowledge on biomarkers of atherosclerosis. Part 1 addressed serological biomarkers. Here, in part 2 we address genetic and imaging markers, and other developments in predicting risk. Further improvements in risk stratification are expected with the addition of genetic risk scores. In addition to single nucleotide polymorphisms (SNPs), recent advances in epigenetics offer DNA methylation profiles, histone chemical modifications, and micro-RNAs as other promising indicators of atherosclerosis. Imaging biomarkers are better studied and already have a higher degree of clinical applicability in cardiovascular (CV) event prediction and detection of preclinical atherosclerosis. With new methodologies, such as proteomics and metabolomics, discoveries of new clinically applicable biomarkers are expected.
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- $a Caprnda, Martin $u 1st Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
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- $a Kubatka, Peter $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia; Department of Experimental Carcinogenesis, Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
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- $a Sinkovič, Andreja $u Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
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- $a Petrovic, Daniel $u Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address: daniel.petrovic@mf.uni-lj.si.
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