• Je něco špatně v tomto záznamu ?

Paclitaxel-Loaded Polylactide/Polyethylene Glycol Fibers with Long-Term Antitumor Activity as a Potential Drug Carrier for Local Chemotherapy

J. Plch, K. Venclikova, O. Janouskova, J. Hrabeta, T. Eckschlager, K. Kopeckova, Z. Hampejsova, Z. Bosakova, J. Sirc, R. Hobzova,

. 2018 ; 18 (6) : e1800011. [pub] 20180424

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19028468

Local application of anticancer agents prolongs the presence time and increases the concentration of drug in the target place and therefore may reduce serious side effects compared to drug systemic administration. The preparation of fibrous materials of polylactide (PLA) and polyethylene glycol (PEG) loaded with paclitaxel (PTX, 1 or 10 wt%) is presented. Scanning electron microscopy proves that PTX is homogeneously incorporated into the fibers. The addition of PEG of various molecular weights (6, 20, or 35 kDa) ensures the release of significantly higher amounts of hydrophobic PTX in a prolonged release time compared to the fibers containing PTX only. Present PLA-PEG fibrous carriers can serve as a drug depot for PTX since they exhibit significant toxicity for cancer cell lines in several-day experiment. They are promising for local recurrence therapy, where the initial release is efficient to kill tumor cells and continued release can prevent their subsequent proliferation.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19028468
003      
CZ-PrNML
005      
20211229081758.0
007      
ta
008      
190813s2018 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1002/mabi.201800011 $2 doi
035    __
$a (PubMed)29688614
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Plch, Johana $u Department of Pediatric Hematology and Oncology, 2nd Medical Faculty, Charles University and Motol University Hospital, V uvalu 84, 150 06, Prague 5, Czech Republic. $7 xx0267889
245    10
$a Paclitaxel-Loaded Polylactide/Polyethylene Glycol Fibers with Long-Term Antitumor Activity as a Potential Drug Carrier for Local Chemotherapy / $c J. Plch, K. Venclikova, O. Janouskova, J. Hrabeta, T. Eckschlager, K. Kopeckova, Z. Hampejsova, Z. Bosakova, J. Sirc, R. Hobzova,
520    9_
$a Local application of anticancer agents prolongs the presence time and increases the concentration of drug in the target place and therefore may reduce serious side effects compared to drug systemic administration. The preparation of fibrous materials of polylactide (PLA) and polyethylene glycol (PEG) loaded with paclitaxel (PTX, 1 or 10 wt%) is presented. Scanning electron microscopy proves that PTX is homogeneously incorporated into the fibers. The addition of PEG of various molecular weights (6, 20, or 35 kDa) ensures the release of significantly higher amounts of hydrophobic PTX in a prolonged release time compared to the fibers containing PTX only. Present PLA-PEG fibrous carriers can serve as a drug depot for PTX since they exhibit significant toxicity for cancer cell lines in several-day experiment. They are promising for local recurrence therapy, where the initial release is efficient to kill tumor cells and continued release can prevent their subsequent proliferation.
650    12
$a protinádorové látky $x chemie $x farmakokinetika $x farmakologie $7 D000970
650    _2
$a léky s prodlouženým účinkem $x chemie $x farmakokinetika $x farmakologie $7 D003692
650    12
$a nosiče léků $x chemie $x farmakokinetika $x farmakologie $7 D004337
650    _2
$a lidé $7 D006801
650    _2
$a MFC-7 buňky $7 D061986
650    _2
$a nádory $x farmakoterapie $x metabolismus $x patologie $7 D009369
650    12
$a paclitaxel $x chemie $x farmakokinetika $x farmakologie $7 D017239
650    12
$a polyestery $x chemie $x farmakokinetika $x farmakologie $7 D011091
650    12
$a polyethylenglykoly $x chemie $x farmakokinetika $x farmakologie $7 D011092
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Venclikova, Kristyna $u Institute of Macromolecular Chemistry, Academy of Sciences, Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic.
700    1_
$a Janouskova, Olga $u Institute of Macromolecular Chemistry, Academy of Sciences, Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic.
700    1_
$a Hrabeta, Jan $u Department of Pediatric Hematology and Oncology, 2nd Medical Faculty, Charles University and Motol University Hospital, V uvalu 84, 150 06, Prague 5, Czech Republic.
700    1_
$a Eckschlager, Tomas $u Department of Pediatric Hematology and Oncology, 2nd Medical Faculty, Charles University and Motol University Hospital, V uvalu 84, 150 06, Prague 5, Czech Republic.
700    1_
$a Kopeckova, Katerina $u Department of Oncology, 2nd Medical Faculty, Charles University and Motol University Hospital, V uvalu 84, 150 06, Prague 5, Czech Republic.
700    1_
$a Hampejsova, Zuzana $u Department of Analytical Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43, Prague 2, Czech Republic.
700    1_
$a Bosakova, Zuzana $u Department of Analytical Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43, Prague 2, Czech Republic.
700    1_
$a Sirc, Jakub $u Institute of Macromolecular Chemistry, Academy of Sciences, Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic.
700    1_
$a Hobzová, Radka, $u Institute of Macromolecular Chemistry, Academy of Sciences, Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic. $d 1976- $7 jo2011640493
773    0_
$w MED00006593 $t Macromolecular bioscience $x 1616-5195 $g Roč. 18, č. 6 (2018), s. e1800011
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29688614 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190813 $b ABA008
991    __
$a 20211229081754 $b ABA008
999    __
$a ok $b bmc $g 1433617 $s 1066928
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 18 $c 6 $d e1800011 $e 20180424 $i 1616-5195 $m Macromolecular bioscience $n Macromol Biosci $x MED00006593
LZP    __
$a Pubmed-20190813

Najít záznam

Citační ukazatele

Možnosti archivace