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Endothelial cell-derived microvesicles: potential mediators and biomarkers of pathologic processes
V. Vítková, J. Živný, J. Janota,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
NV16-27800A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
NLK
PubMed Central
od 2015 do Před 1 rokem
ProQuest Central
od 2007-06-01 do 2021-01-31
Health & Medicine (ProQuest)
od 2007-06-01 do 2021-01-31
Public Health Database (ProQuest)
od 2007-06-01 do 2021-01-31
PubMed
29327597
DOI
10.2217/bmm-2017-0182
Knihovny.cz E-zdroje
- MeSH
- apoptóza MeSH
- biologické markery metabolismus MeSH
- endoteliální buňky cytologie metabolismus MeSH
- exozómy metabolismus MeSH
- extracelulární vezikuly metabolismus MeSH
- lidé MeSH
- mikropartikule metabolismus MeSH
- patologická angiogeneze MeSH
- trombóza patologie MeSH
- zánět patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
This review focuses on the formation, composition and function of endothelial microvesicles (MV), often called microparticles (MP). MV release is a controlled event and is considered a hallmark of cellular activation or alteration. MV may affect the function of target cells through surface interaction and receptor activation, cellular fusion and the delivery of intravesicular cargo. Endothelial MV are released as a consequence of endothelial activation during inflammation and have been described to affect hemostasis, various aspects of inflammatory reaction, vessel formation, apoptosis and cell survival, endothelial cell differentiation and function. Recent data suggest the potential use of MV in diagnostics, assessment of severity and prediction of outcomes in inflammatory diseases and their utilization as targets, mediators and vectors in therapy.
Citace poskytuje Crossref.org
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