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Hormonal and bone parameters in pubertal girls
V. Cirmanova, I. Zofkova, P. Kasalicky, V. Lanska, M. Bayer, L. Starka, R. Kanceva
Language English Country Czech Republic
Document type Journal Article
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- MeSH
- Exercise physiology MeSH
- Child MeSH
- Estradiol blood MeSH
- Insulin-Like Growth Factor I metabolism MeSH
- Calcifediol blood MeSH
- Bone Density physiology MeSH
- Leptin blood MeSH
- Humans MeSH
- Adolescent MeSH
- Osteocalcin blood MeSH
- Puberty metabolism MeSH
- Body Composition physiology MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Here we analyzed associations between muscles mass, total bone mineral content (BMC), lumbar spine bone density (BMD L1-L4) and serum or urine hormones in healthy peripubertal girls. Total BMC and areal BMD L1-L4, muscle mass and fat were measured by dual-energy X-ray absorptiometry (DXA). Muscle force (N) was estimated by a dynamometer. Circulating estradiol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), 25-hydroxy vitamin D, parathyroid hormone (PTH), insulin-like growth factor 1 (IGF-1), leptin, osteocalcin, bone isoenzyme of alkaline phosphatase (bALP) and total calcium and phosphorus were quantified as the nocturnal melatonin and serotonin urinary excretion. Partial correlations adjusted for height, Tanner score and physical activity confirmed positive relationships between BMC or BMD L1-L4 (Z-score) and lean mass or fat. Furthermore, positive relationship was observed between BMC or BMD L1-L4 (Z-score) and serum leptin. After adjustment for Tanner score and physical activity, positive associations were observed between lean mass and IGF-1, leptin levels or muscle force. We proved positive relationships between bone mass and serum leptin in peripubertal girls.
Institute of Endocrinology Prague Czech Republic
Instituteof Clinical and Experimental Medicine Prague Czech Republic
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