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Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus
A. Guilherme, F. Henriques, AH. Bedard, MP. Czech,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu srovnávací studie, časopisecké články, Research Support, N.I.H., Extramural, přehledy
Grantová podpora
R01 DK030898
NIDDK NIH HHS - United States
NLK
ProQuest Central
od 2009-04-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2009-04-01 do Před 1 rokem
- MeSH
- diabetes mellitus 2. typu metabolismus patofyziologie MeSH
- energetický metabolismus genetika MeSH
- homeostáza genetika MeSH
- inzulin metabolismus MeSH
- inzulinová rezistence fyziologie MeSH
- lidé MeSH
- lipogeneze genetika MeSH
- lipolýza genetika MeSH
- mezibuněčná komunikace genetika MeSH
- molekulární biologie MeSH
- obezita metabolismus patofyziologie MeSH
- senzitivita a specificita MeSH
- signální transdukce * MeSH
- sympatický nervový systém fyziologie MeSH
- tukové buňky cytologie metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
- srovnávací studie MeSH
Adipose tissue comprises adipocytes and many other cell types that engage in dynamic crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has been studied for decades, it has been appreciated only in the past 5 years that extensive arborization of nerve fibres has a dominant role in regulating the function of adipose tissue. This Review summarizes the latest literature, which suggests that adipocytes signal to local sensory nerve fibres in response to perturbations in lipolysis and lipogenesis. Such adipocyte signalling to the central nervous system causes sympathetic output to distant adipose depots and potentially other metabolic tissues to regulate systemic glucose homeostasis. Paracrine factors identified in the past few years that mediate such adipocyte-neuron crosstalk are also reviewed. Similarly, immune cells and endothelial cells within adipose tissue communicate with local nerve fibres to modulate neurotransmitter tone, blood flow, adipocyte differentiation and energy expenditure, including adipose browning to produce heat. This understudied field of neurometabolism related to adipose tissue biology has great potential to reveal new mechanistic insights and potential therapeutic strategies for obesity and type 2 diabetes mellitus.
Citace poskytuje Crossref.org
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- $a Adipose tissue comprises adipocytes and many other cell types that engage in dynamic crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has been studied for decades, it has been appreciated only in the past 5 years that extensive arborization of nerve fibres has a dominant role in regulating the function of adipose tissue. This Review summarizes the latest literature, which suggests that adipocytes signal to local sensory nerve fibres in response to perturbations in lipolysis and lipogenesis. Such adipocyte signalling to the central nervous system causes sympathetic output to distant adipose depots and potentially other metabolic tissues to regulate systemic glucose homeostasis. Paracrine factors identified in the past few years that mediate such adipocyte-neuron crosstalk are also reviewed. Similarly, immune cells and endothelial cells within adipose tissue communicate with local nerve fibres to modulate neurotransmitter tone, blood flow, adipocyte differentiation and energy expenditure, including adipose browning to produce heat. This understudied field of neurometabolism related to adipose tissue biology has great potential to reveal new mechanistic insights and potential therapeutic strategies for obesity and type 2 diabetes mellitus.
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