-
Je něco špatně v tomto záznamu ?
Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature
R. Dobias, M. Filip, K. Vragova, D. Dolinska, P. Zavodna, A. Dujka, P. Linzer, P. Jurek, B. Studena, E. Cerna, J. Mrazek, P. Jaworska, M. Kantorova, P. Lyskova, E. Krejci, V. Hubka,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu kazuistiky, časopisecké články, přehledy
Grantová podpora
204069
Ministerstvo Školství, Mládeže a Tělovýchovy
- MeSH
- absces mozku diagnostické zobrazování mikrobiologie chirurgie MeSH
- amfotericin B terapeutické užití MeSH
- antifungální látky farmakologie terapeutické užití MeSH
- Ascomycota účinky léků genetika izolace a purifikace MeSH
- imunokompetence MeSH
- lidé středního věku MeSH
- lidé MeSH
- mykózy diagnóza diagnostické zobrazování MeSH
- ribozomální DNA genetika MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- přehledy MeSH
- Geografické názvy
- Česká republika MeSH
Cerebral abscesses caused by dark-pigmented Fonsecaea fungi are rare, especially in otherwise healthy individuals. In this case report, we present a 61-year-old man from Moldova, living in the Czech Republic, who had worked as a locksmith on oil platforms in Turkmenistan, Kazakhstan, Sudan, and Iraq since 1999, and was admitted to a neurology ward for a sudden motion disorder of the right leg, dysarthria, and hypomimia. Imaging revealed presence of expansive focus around the left lateral ventricle of the brain and a pronounced peripheral edema. The intracranial infectious focus was excised under intraoperative SonoWand guidance. Tissue samples were histologically positive for dark-pigmented hyphae, suggesting dematiaceous fungi. Therefore, liposomal amphotericin B therapy was initiated immediately. Fonsecaea monophora was provisionally identified using ITS rDNA region sequencing directly from brain tissue. The identification was subsequently confirmed by cultivation and DNA sequencing from culture. The strain exhibited in vitro sensitive to voriconazole (MIC = 0.016 μg/mL) and resistance to amphotericin B (MIC = 4 μg/mL); therefore, the amphotericin B was replaced with voriconazole. Postoperatively, a significant clinical improvement was observed and no additional surgery was required. Based on the literature review, this is the third documented case of cerebral infection due to this pathogen in patients without underlying conditions and the first such case in Europe.
Department of Bacteriology and Mycology Institute of Public Health in Ostrava Ostrava Czech Republic
Department of Infectious Diseases Uherske Hradiste Hospital Uherske Hradiste Czech Republic
Department of Molecular Biology Institute of Public Health in Ostrava Ostrava Czech Republic
Neurosurgery Tomas Bata Regional Hospital Zlin Czech Republic
Pathological and Anatomical Department Tomas Bata Regional Hospital Zlin Czech Republic
Radiodiagnostic Department Uherske Hradiste Hospital Uherske Hradiste Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19036105
- 003
- CZ-PrNML
- 005
- 20191118131218.0
- 007
- ta
- 008
- 191007s2019 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s12223-018-0661-9 $2 doi
- 035 __
- $a (PubMed)30368648
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Dobias, Radim $u Department of Bacteriology and Mycology, Institute of Public Health in Ostrava, Ostrava, Czech Republic. radim.dobias@seznam.cz. Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic. radim.dobias@seznam.cz.
- 245 10
- $a Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature / $c R. Dobias, M. Filip, K. Vragova, D. Dolinska, P. Zavodna, A. Dujka, P. Linzer, P. Jurek, B. Studena, E. Cerna, J. Mrazek, P. Jaworska, M. Kantorova, P. Lyskova, E. Krejci, V. Hubka,
- 520 9_
- $a Cerebral abscesses caused by dark-pigmented Fonsecaea fungi are rare, especially in otherwise healthy individuals. In this case report, we present a 61-year-old man from Moldova, living in the Czech Republic, who had worked as a locksmith on oil platforms in Turkmenistan, Kazakhstan, Sudan, and Iraq since 1999, and was admitted to a neurology ward for a sudden motion disorder of the right leg, dysarthria, and hypomimia. Imaging revealed presence of expansive focus around the left lateral ventricle of the brain and a pronounced peripheral edema. The intracranial infectious focus was excised under intraoperative SonoWand guidance. Tissue samples were histologically positive for dark-pigmented hyphae, suggesting dematiaceous fungi. Therefore, liposomal amphotericin B therapy was initiated immediately. Fonsecaea monophora was provisionally identified using ITS rDNA region sequencing directly from brain tissue. The identification was subsequently confirmed by cultivation and DNA sequencing from culture. The strain exhibited in vitro sensitive to voriconazole (MIC = 0.016 μg/mL) and resistance to amphotericin B (MIC = 4 μg/mL); therefore, the amphotericin B was replaced with voriconazole. Postoperatively, a significant clinical improvement was observed and no additional surgery was required. Based on the literature review, this is the third documented case of cerebral infection due to this pathogen in patients without underlying conditions and the first such case in Europe.
- 650 _2
- $a amfotericin B $x terapeutické užití $7 D000666
- 650 _2
- $a antifungální látky $x farmakologie $x terapeutické užití $7 D000935
- 650 _2
- $a Ascomycota $x účinky léků $x genetika $x izolace a purifikace $7 D001203
- 650 _2
- $a absces mozku $x diagnostické zobrazování $x mikrobiologie $x chirurgie $7 D001922
- 650 _2
- $a ribozomální DNA $x genetika $7 D004275
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunokompetence $7 D007121
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a mykózy $x diagnóza $x diagnostické zobrazování $7 D009181
- 650 _2
- $a výsledek terapie $7 D016896
- 651 _2
- $a Česká republika $7 D018153
- 655 _2
- $a kazuistiky $7 D002363
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Filip, Michal $u Neurosurgery, Tomas Bata Regional Hospital, Zlin, Czech Republic. Department of Rehabilitation, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
- 700 1_
- $a Vragova, Katerina $u Department of Infectious Diseases, Uherske Hradiste Hospital, Uherske Hradiste, Czech Republic.
- 700 1_
- $a Dolinska, Dagmar $u Pathological and Anatomical Department, Tomas Bata Regional Hospital, Zlin, Czech Republic.
- 700 1_
- $a Zavodna, Petra $u Department of Infectious Diseases, Uherske Hradiste Hospital, Uherske Hradiste, Czech Republic.
- 700 1_
- $a Dujka, Ales $u Radiodiagnostic Department, Uherske Hradiste Hospital, Uherske Hradiste, Czech Republic.
- 700 1_
- $a Linzer, Petr $7 xx0242115 $u Neurosurgery, Tomas Bata Regional Hospital, Zlin, Czech Republic.
- 700 1_
- $a Jurek, Patrik $u Neurosurgery, Tomas Bata Regional Hospital, Zlin, Czech Republic.
- 700 1_
- $a Studena, Barbora $u Pathological and Anatomical Department, Tomas Bata Regional Hospital, Zlin, Czech Republic.
- 700 1_
- $a Cerna, Eva $u Department of Infectious Diseases, Uherske Hradiste Hospital, Uherske Hradiste, Czech Republic.
- 700 1_
- $a Mrazek, Jakub $u Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic. Department of Molecular Biology, Institute of Public Health in Ostrava, Ostrava, Czech Republic.
- 700 1_
- $a Jaworska, Pavla $u Department of Bacteriology and Mycology, Institute of Public Health in Ostrava, Ostrava, Czech Republic.
- 700 1_
- $a Kantorova, Michaela $u Department of Molecular Biology, Institute of Public Health in Ostrava, Ostrava, Czech Republic.
- 700 1_
- $a Lyskova, Pavlina $u Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic. Department of Parasitology, Mycology and Mycobacteriology Prague, Public Health Institute in Usti nad Labem, Prague, Czech Republic.
- 700 1_
- $a Krejci, Eva $u Department of Bacteriology and Mycology, Institute of Public Health in Ostrava, Ostrava, Czech Republic. Department of Biomedical Science, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
- 700 1_
- $a Hubka, Vit $u Department of Botany, Faculty of Science, Charles University, Prague, Czech Republic. Laboratory of Fungal Genetics and Metabolism, Institute of Microbiology of the AS CR, Prague, Czech Republic.
- 773 0_
- $w MED00011005 $t Folia microbiologica $x 1874-9356 $g Roč. 64, č. 3 (2019), s. 383-388
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/30368648 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20191007 $b ABA008
- 991 __
- $a 20191118131459 $b ABA008
- 999 __
- $a ok $b bmc $g 1452752 $s 1074662
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 64 $c 3 $d 383-388 $e 20181027 $i 1874-9356 $m Folia microbiologica $n Folia microbiol. (Prague) $x MED00011005
- GRA __
- $a 204069 $p Ministerstvo Školství, Mládeže a Tělovýchovy
- LZP __
- $a Pubmed-20191007
