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Plasma Levels of Myocardial MicroRNA-133a Increase by Intraoperative Cytokine Hemoadsorption in the Complex Cardiovascular Operation

R. Wagner, P. Soucek, J. Ondrasek, P. Fila, J. Sterba, H. Spacilova, A. Michalcikova, T. Freiberger, P. Nemec,

. 2019 ; 11 (12) : 789-797. [pub] 20191124

Language English Country Canada

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19043951

Background: Complex cardiovascular procedures may initiate a systemic inflammatory response syndrome (SIRS) with a massive cytokine release, which is involved in postoperative myocardial injury. Intraoperative cytokine hemoadsorption (HA) mitigates the inflammatory response. Micro ribonucleic acids (miRNAs) are emerging as a marker of myocardial injury. Methods: This study evaluated if intraoperative cytokine reduction by HA modulates SIRS and affects myocardial injury as measured by miRNA-126, 223 and miRNA-1, 133a, respectively. Twenty-eight patients were assigned into HA (n = 15) and control (C) (n = 13) groups. HA was performed by integrating CytoSorb™ into the extracorporeal circuit. Results: MiRNA-133a plasma levels were increased postoperatively in both groups but were much higher in the HA group than in the C group at 3 h (P = 0.037) and 18 h (P = 0.017) after reperfusion. MiRNA-1 and miRNA-223 plasma levels were significantly increased postoperatively, but did not differ between groups. The vascular miRNA-126 was not affected. Conclusion: Intraoperative cytokine HA in cardiovascular operations increased the plasma levels of miRNA-133a, suggesting higher myocardial injury.

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$a Background: Complex cardiovascular procedures may initiate a systemic inflammatory response syndrome (SIRS) with a massive cytokine release, which is involved in postoperative myocardial injury. Intraoperative cytokine hemoadsorption (HA) mitigates the inflammatory response. Micro ribonucleic acids (miRNAs) are emerging as a marker of myocardial injury. Methods: This study evaluated if intraoperative cytokine reduction by HA modulates SIRS and affects myocardial injury as measured by miRNA-126, 223 and miRNA-1, 133a, respectively. Twenty-eight patients were assigned into HA (n = 15) and control (C) (n = 13) groups. HA was performed by integrating CytoSorb™ into the extracorporeal circuit. Results: MiRNA-133a plasma levels were increased postoperatively in both groups but were much higher in the HA group than in the C group at 3 h (P = 0.037) and 18 h (P = 0.017) after reperfusion. MiRNA-1 and miRNA-223 plasma levels were significantly increased postoperatively, but did not differ between groups. The vascular miRNA-126 was not affected. Conclusion: Intraoperative cytokine HA in cardiovascular operations increased the plasma levels of miRNA-133a, suggesting higher myocardial injury.
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$a Fila, Petr $u Department of Cardiovascular Surgery, Centre for Cardiovascular and Transplant Surgery (CKTCH), Pekarska 53, Brno, Czech Republic.
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$a Sterba, Jan $u Department of Cardiovascular Surgery, Centre for Cardiovascular and Transplant Surgery (CKTCH), Pekarska 53, Brno, Czech Republic.
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$a Spacilova, Hana $u Department of Hematological Laboratory, Centre for Cardiovascular and Transplant Surgery (CKTCH), Pekarska 53, Brno, Czech Republic.
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$a Michalcikova, Alzbeta $u Department of Psychology, Centre for Cardiovascular and Transplant Surgery (CKTCH), Pekarska 53, Brno, Czech Republic.
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