Food contact materials (FCMs) may release their chemical components into food and thus raise safety concerns. This paper attempted to study the presence of four major groups of FCM-related endocrine disruptors in fatty food: dialkyl phthalates, bisphenols, printing ink photoinitiators, and polyfluoroalkyl substances. All 41 target compounds were analyzed simultaneously by means of liquid chromatography coupled to tandem mass spectrometry. The sample preparation was significantly streamlined to reduce analysis costs by employing acetonitrile extraction, extract modification by water, and refrigeration at 5 °C. The new method was validated and applied to 60 real samples, including edible oils, butter, and chocolate, where 16 target compounds were measured at levels ≤13000 ng/g. The study also described the blank level increase and sensitivity loss caused by impurities present in the HPLC methanol solvent.

Centre of Toxicology and Health Safety National Institute of Public Health Srobarova 48 100 00 Praha 10 Czech Republic

Centre of Toxicology and Health Safety National Institute of Public Health Srobarova 48 100 00 Praha 10 Czech Republic 3rd Faculty of Medicine Charles University Prague Ruska 87 100 00 Prague 10 Czech Republic

Centre of Toxicology and Health Safety National Institute of Public Health Srobarova 48 100 00 Praha 10 Czech Republic Department of Analytical Chemistry Faculty of Science Charles University Prague Hlavova 8 128 43 Praha 2 Czech Republic

Department of Analytical Chemistry Faculty of Science Charles University Prague Hlavova 8 128 43 Praha 2 Czech Republic Institute of Forensic Medicine and Toxicology 1st Faculty of Medicine Charles University Prague and General University Hospital 121 08 Prague 2 Czech Republic

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