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Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy
S. Balaji, MP. DiLorenzo, FA. Fish, SP. Etheridge, PF. Aziz, MW. Russell, S. Tisma, A. Pflaumer, N. Sreeram, P. Kubus, IH. Law, MJ. Kantoch, NJ. Kertesz, M. Strieper, CC. Erickson, JP. Moore, SJ. Nakano, HR. Singh, P. Chang, M. Cohen, A....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
CR-1651
Medtronic
- MeSH
- dítě MeSH
- echokardiografie MeSH
- hypertrofická kardiomyopatie komplikace patofyziologie MeSH
- index tělesné hmotnosti MeSH
- lidé MeSH
- mezikomorová přepážka patologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- obezita komplikace MeSH
- předškolní dítě MeSH
- srdeční komory patologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients' weight and height were recorded. Obesity was defined as a body mass index (BMI) ≥ 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean ± SD, 12.5 ± 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 ± 6.1). Obesity (BMI 18-50, mean 29.1) was present in 140 children aged 2-19.6 (11.3 ± 4.1). The overall mean IVST was 20.5 ± 9.6 mm and the overall mean PWT was 11.0 ± 8.4 mm. The mean IVST in the obese patients was 21.6 ± 10.0 mm and mean PWT was 13.3 ± 14.7 mm. The mean IVST in the non-obese patients was 20.1 ± 9.5 mm and mean PWT was 10.4 ± 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.
Advocate Hospital Chicago Chicago IL USA
Carolinas Health System Charlotte NC USA
Children's Hospital of Michigan Detroit MI USA Children's Hospital of San Antonio San Antonio TX USA
Children's Hospital of Omaha Omaha NE USA
Children's Hospital of Philadelphia Philadelphia PA USA
Cleveland Clinic Cleveland OH USA
Columbia University New York NY USA
German Heart Center Munich Munich Germany
Hospital for Sick Kids Toronto ON Canada
Mercy Children's Hospital Kansas City MO USA
Montefiore Hospital New York NY USA
Motol University Prague Czech Republic
Nationwide Children's Hospital Columbus OH USA
Northshore Hofstra University Hempstead NY USA
Phoenix Children's Hospital Phoenix AZ USA
Royal Children's Glasgow Glasgow UK
Royal Children's Melbourne Parkville VIC Australia
Sibley Heart Center Atlanta GA USA
St Louis University St Louis MO USA
University of Alberta Edmonton AB Canada
University of British Columbia Vancouver BC Canada
University of Cologne Cologne Germany
University of Colorado Boulder CO USA
University of Iowa Iowa City IA USA
University of Michigan Ann Arbor MI USA
University of Montreal Montreal QC Canada
University of Texas Southwestern Dallas TX USA
University of Utah Salt Lake City UT USA
Citace poskytuje Crossref.org
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- $a Balaji, Seshadri $u Division of Cardiology, Department of Pediatrics, Oregon Health & Science University, 707, SW Gaines Street, Mailcode: CDRC-P, Portland, OR, 97239, USA. balajis@ohsu.edu.
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- $a Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients' weight and height were recorded. Obesity was defined as a body mass index (BMI) ≥ 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean ± SD, 12.5 ± 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 ± 6.1). Obesity (BMI 18-50, mean 29.1) was present in 140 children aged 2-19.6 (11.3 ± 4.1). The overall mean IVST was 20.5 ± 9.6 mm and the overall mean PWT was 11.0 ± 8.4 mm. The mean IVST in the obese patients was 21.6 ± 10.0 mm and mean PWT was 13.3 ± 14.7 mm. The mean IVST in the non-obese patients was 20.1 ± 9.5 mm and mean PWT was 10.4 ± 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.
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