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Surface plasmon resonance biosensor for the ultrasensitive detection of bisphenol A
CS. Xue, G. Erika, H. Jiří,
Language English Country Germany
Document type Journal Article
Grant support
16-27611A
Ministry of Health of the Czech Republic
NLK
ProQuest Central
from 2011-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2003-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2011-01-01 to 1 year ago
- MeSH
- Benzhydryl Compounds analysis MeSH
- Biosensing Techniques * MeSH
- Phenols analysis MeSH
- Metal Nanoparticles chemistry MeSH
- Limit of Detection MeSH
- Surface Plasmon Resonance instrumentation MeSH
- Reproducibility of Results MeSH
- Gold chemistry MeSH
- Publication type
- Journal Article MeSH
Bisphenol A (BpA) is a chemical that is extensively used in common plastic products, such as food and drink containers. It can leach from the plastics and penetrate into the human body, where it acts as an endocrine disruptor with significant risks to human health. In order to minimize the exposure of human populations to BpA, methods for the detection of BpA are needed. In this work, we present a novel surface plasmon resonance (SPR) biosensor for ultrasensitive detection of BpA. Our approach combines a binding inhibition assay with functionalized gold nanoparticles for the enhancement of sensor response. We demonstrate that the developed biosensor enables the detection of BpA in a wide range of concentrations (0.01 to 100,000 ng/mL) with an extremely low limit of detection-5.2 pg/mL.
References provided by Crossref.org
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