-
Je něco špatně v tomto záznamu ?
Antibiotics, gut microbiota, and Alzheimer's disease
F. Angelucci, K. Cechova, J. Amlerova, J. Hort,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, přehledy
Grantová podpora
LF UK Grant No. 699012
Ipe 2
BioMedCentral Open Access od 2004
Directory of Open Access Journals od 2004
Free Medical Journals od 2004
PubMed Central od 2004
Europe PubMed Central od 2004
ProQuest Central od 2009-01-01
Open Access Digital Library od 2004-01-01
Open Access Digital Library od 2004-01-01
Open Access Digital Library od 2004-04-01
Health & Medicine (ProQuest) od 2009-01-01
Springer Journals Complete - Open Access od 2004-12-01
Springer Nature OA/Free Journals od 2004-12-01
Odkazy
PubMed
31118068
DOI
10.1186/s12974-019-1494-4
Knihovny.cz E-zdroje
- MeSH
- Alzheimerova nemoc chemicky indukované farmakoterapie mikrobiologie MeSH
- antibakteriální látky aplikace a dávkování škodlivé účinky MeSH
- dysbióza chemicky indukované mikrobiologie MeSH
- lidé MeSH
- mozek účinky léků fyziologie MeSH
- probiotika aplikace a dávkování škodlivé účinky MeSH
- střevní mikroflóra účinky léků fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Alzheimer's disease (AD) is a neurodegenerative disease whose various pathophysiological aspects are still being investigated. Recently, it has been hypothesized that AD may be associated with a dysbiosis of microbes in the intestine. In fact, the intestinal flora is able to influence the activity of the brain and cause its dysfunctions.Given the growing interest in this topic, the purpose of this review is to analyze the role of antibiotics in relation to the gut microbiota and AD. In the first part of the review, we briefly review the role of gut microbiota in the brain and the various theories supporting the hypothesis that dysbiosis can be associated with AD pathophysiology. In the second part, we analyze the possible role of antibiotics in these events. Antibiotics are normally used to remove or prevent bacterial colonization in the human body, without targeting specific types of bacteria. As a result, broad-spectrum antibiotics can greatly affect the composition of the gut microbiota, reduce its biodiversity, and delay colonization for a long period after administration. Thus, the action of antibiotics in AD could be wide and even opposite, depending on the type of antibiotic and on the specific role of the microbiome in AD pathogenesis.Alteration of the gut microbiota can induce changes in brain activity, which raise the possibility of therapeutic manipulation of the microbiome in AD and other neurological disorders. This field of research is currently undergoing great development, but therapeutic applications are still far away. Whether a therapeutic manipulation of gut microbiota in AD could be achieved using antibiotics is still not known. The future of antibiotics in AD depends on the research progresses in the role of gut bacteria. We must first understand how and when gut bacteria act to promote AD. Once the role of gut microbiota in AD is well established, one can think to induce modifications of the gut microbiota with the use of pre-, pro-, or antibiotics to produce therapeutic effects.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19044813
- 003
- CZ-PrNML
- 005
- 20200115101856.0
- 007
- ta
- 008
- 200109s2019 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1186/s12974-019-1494-4 $2 doi
- 035 __
- $a (PubMed)31118068
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Angelucci, Francesco $u Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic. francesco.angelucci@lfmotol.cuni.cz.
- 245 10
- $a Antibiotics, gut microbiota, and Alzheimer's disease / $c F. Angelucci, K. Cechova, J. Amlerova, J. Hort,
- 520 9_
- $a Alzheimer's disease (AD) is a neurodegenerative disease whose various pathophysiological aspects are still being investigated. Recently, it has been hypothesized that AD may be associated with a dysbiosis of microbes in the intestine. In fact, the intestinal flora is able to influence the activity of the brain and cause its dysfunctions.Given the growing interest in this topic, the purpose of this review is to analyze the role of antibiotics in relation to the gut microbiota and AD. In the first part of the review, we briefly review the role of gut microbiota in the brain and the various theories supporting the hypothesis that dysbiosis can be associated with AD pathophysiology. In the second part, we analyze the possible role of antibiotics in these events. Antibiotics are normally used to remove or prevent bacterial colonization in the human body, without targeting specific types of bacteria. As a result, broad-spectrum antibiotics can greatly affect the composition of the gut microbiota, reduce its biodiversity, and delay colonization for a long period after administration. Thus, the action of antibiotics in AD could be wide and even opposite, depending on the type of antibiotic and on the specific role of the microbiome in AD pathogenesis.Alteration of the gut microbiota can induce changes in brain activity, which raise the possibility of therapeutic manipulation of the microbiome in AD and other neurological disorders. This field of research is currently undergoing great development, but therapeutic applications are still far away. Whether a therapeutic manipulation of gut microbiota in AD could be achieved using antibiotics is still not known. The future of antibiotics in AD depends on the research progresses in the role of gut bacteria. We must first understand how and when gut bacteria act to promote AD. Once the role of gut microbiota in AD is well established, one can think to induce modifications of the gut microbiota with the use of pre-, pro-, or antibiotics to produce therapeutic effects.
- 650 _2
- $a Alzheimerova nemoc $x chemicky indukované $x farmakoterapie $x mikrobiologie $7 D000544
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a antibakteriální látky $x aplikace a dávkování $x škodlivé účinky $7 D000900
- 650 _2
- $a mozek $x účinky léků $x fyziologie $7 D001921
- 650 _2
- $a dysbióza $x chemicky indukované $x mikrobiologie $7 D064806
- 650 _2
- $a střevní mikroflóra $x účinky léků $x fyziologie $7 D000069196
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a probiotika $x aplikace a dávkování $x škodlivé účinky $7 D019936
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Cechova, Katerina $u Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
- 700 1_
- $a Amlerova, Jana $u Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
- 700 1_
- $a Hort, Jakub $u Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
- 773 0_
- $w MED00163330 $t Journal of neuroinflammation $x 1742-2094 $g Roč. 16, č. 1 (2019), s. 108
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31118068 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200109 $b ABA008
- 991 __
- $a 20200115102229 $b ABA008
- 999 __
- $a ok $b bmc $g 1483082 $s 1083486
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 16 $c 1 $d 108 $e 20190522 $i 1742-2094 $m Journal of neuroinflammation $n J Neuroinflammation $x MED00163330
- GRA __
- $a LF UK Grant No. 699012 $p Ipe 2
- LZP __
- $a Pubmed-20200109