-
Je něco špatně v tomto záznamu ?
Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study
S. Rejchrt, M. Hroch, R. Repak, T. Fejfar, T. Douda, D. Kohoutova, E. Peterova, J. Bures,
Jazyk angličtina Země Egypt
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2008
Free Medical Journals
od 2008
PubMed Central
od 2008
Europe PubMed Central
od 2008
ProQuest Central
od 2008-01-01
Open Access Digital Library
od 2008-01-01
Open Access Digital Library
od 2008-03-19
Open Access Digital Library
od 2008-01-01
Wiley-Blackwell Open Access Titles
od 2008
ROAD: Directory of Open Access Scholarly Resources
od 2007
PubMed
31929784
DOI
10.1155/2019/5371381
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
Differential diagnosis between benign and malignant biliary stenosis can be difficult in clinical practice. Histology of biopsy specimens is often indeterminate. Laboratory markers (serum bilirubin > 75 μmol/L, carbohydrate antigen 19-9 > 400 U/mL) and the length of stenosis (>15 mm) can be helpful but are not specific enough. The aim of this study was to investigate bile acids in liver bile of patients with benign and malignant biliary stenosis and controls without stenosis. A total of 73 patients entered the study: 7 subjects with benign biliary stenosis (6 men, 1 woman; 68 ± 13 years old), 21 with malignant biliary stenosis (15 men, 6 women; 72 ± 14 years old), and 45 patients without biliary stenosis (22 men, 23 women; 70 ± 13 years old); out of those, 25 subjects have and 20 do not have choledocholithiasis. Twenty-three different bile acids were investigated by high-performance liquid chromatography/mass spectrometry. Serum total bilirubin was significantly higher in patients with malignant biliary stenosis compared with nonstenotic controls (p = 0.005). Significant relationship (r > 0.7) was found between several pairs of bile acids. Significantly lower bile acid concentrations in malignant biliary stenosis compared to controls without stenosis were found for GLCA (p = 0.032), GUDCA (p = 0.032), GCDCA (p = 0.006), GDCA (p = 0.031), GHCA (p = 0.005), TUDCA (p = 0.044), and TDCA (p = 0.036). Significant difference in cholic acid was found between benign and malignant stenosis (p = 0.022). Analysis of bile acids might be helpful in the differential diagnosis of malignant and benign biliary stenosis. More patients need to be enrolled in further studies so that the real diagnostic yield of bile acids can be determined.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20005390
- 003
- CZ-PrNML
- 005
- 20200526104549.0
- 007
- ta
- 008
- 200511s2019 ua f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1155/2019/5371381 $2 doi
- 035 __
- $a (PubMed)31929784
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ua
- 100 1_
- $a Rejchrt, Stanislav $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
- 245 10
- $a Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study / $c S. Rejchrt, M. Hroch, R. Repak, T. Fejfar, T. Douda, D. Kohoutova, E. Peterova, J. Bures,
- 520 9_
- $a Differential diagnosis between benign and malignant biliary stenosis can be difficult in clinical practice. Histology of biopsy specimens is often indeterminate. Laboratory markers (serum bilirubin > 75 μmol/L, carbohydrate antigen 19-9 > 400 U/mL) and the length of stenosis (>15 mm) can be helpful but are not specific enough. The aim of this study was to investigate bile acids in liver bile of patients with benign and malignant biliary stenosis and controls without stenosis. A total of 73 patients entered the study: 7 subjects with benign biliary stenosis (6 men, 1 woman; 68 ± 13 years old), 21 with malignant biliary stenosis (15 men, 6 women; 72 ± 14 years old), and 45 patients without biliary stenosis (22 men, 23 women; 70 ± 13 years old); out of those, 25 subjects have and 20 do not have choledocholithiasis. Twenty-three different bile acids were investigated by high-performance liquid chromatography/mass spectrometry. Serum total bilirubin was significantly higher in patients with malignant biliary stenosis compared with nonstenotic controls (p = 0.005). Significant relationship (r > 0.7) was found between several pairs of bile acids. Significantly lower bile acid concentrations in malignant biliary stenosis compared to controls without stenosis were found for GLCA (p = 0.032), GUDCA (p = 0.032), GCDCA (p = 0.006), GDCA (p = 0.031), GHCA (p = 0.005), TUDCA (p = 0.044), and TDCA (p = 0.036). Significant difference in cholic acid was found between benign and malignant stenosis (p = 0.022). Analysis of bile acids might be helpful in the differential diagnosis of malignant and benign biliary stenosis. More patients need to be enrolled in further studies so that the real diagnostic yield of bile acids can be determined.
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Hroch, Milos $u Department of Medical Biochemistry, Charles University, Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
- 700 1_
- $a Repak, Rudolf $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
- 700 1_
- $a Fejfar, Tomas $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
- 700 1_
- $a Douda, Tomas $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
- 700 1_
- $a Kohoutova, Darina $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, SW3 6JJ London, UK.
- 700 1_
- $a Peterova, Eva $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. Department of Medical Biochemistry, Charles University, Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
- 700 1_
- $a Bures, Jan $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
- 773 0_
- $w MED00163225 $t Gastroenterology research and practice $x 1687-6121 $g Roč. 2019, č. - (2019), s. 5371381
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31929784 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200511 $b ABA008
- 991 __
- $a 20200526104545 $b ABA008
- 999 __
- $a ind $b bmc $g 1524320 $s 1095445
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 2019 $c - $d 5371381 $e 20191218 $i 1687-6121 $m Gastroenterology Research and Practice $n Gastroenterol Res Pract $x MED00163225
- LZP __
- $a Pubmed-20200511