• Je něco špatně v tomto záznamu ?

Assessment of the effective impact of bisphenols on mitochondrial activity and steroidogenesis in a dose-dependency in mice TM3 Leydig cells

T. Jambor, E. Kovacikova, H. Greifova, A. Kovacik, L. Libova, N. Lukac

. 2019 ; 68 (4) : 689-693. [pub] 20190725

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20005471

The increasing worldwide production of bisphenols has been associated to several human diseases, such as chronic respiratory and kidney diseases, diabetes, breast cancer, prostate cancer, behavioral troubles and reproductive disorders in both sexes. The aim of the present in vitro study was to evaluate the potential impact bisphenols A, B, S and F on the cell viability and testosterone release in TM3 Leydig cell line. Mice Leydig cells were cultured in the presence of different concentrations of bisphenols (0.04-50 µg.ml-1) during 24 h exposure. Quantification of the cell viability was assessed using the metabolic activity assay, while the level of testosterone in cell culture media was determined by enzyme-linked immunosorbent assay. Within the panel of substances under investigations, the higher experimental concentrations (10; 25 and 50 µg.ml-1) significantly (P<0.001) decreased Leydig cells viability, while the same doses of BPA and BPB also reduced testosterone production significantly (P<0.001). Taken together, the results of our study reported herein is a consistent whit the conclusion that higher experimental doses of bisphenols have a cytotoxic effect and could have a dose-dependent impact on testosterone production.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc20005471
003      
CZ-PrNML
005      
20200603084608.0
007      
ta
008      
200511s2019 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934200 $2 doi
035    __
$a (PubMed)31342755
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Jambor, Tomáš. $7 xx0248602 $u Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic
245    10
$a Assessment of the effective impact of bisphenols on mitochondrial activity and steroidogenesis in a dose-dependency in mice TM3 Leydig cells / $c T. Jambor, E. Kovacikova, H. Greifova, A. Kovacik, L. Libova, N. Lukac
504    __
$a Literatura
520    9_
$a The increasing worldwide production of bisphenols has been associated to several human diseases, such as chronic respiratory and kidney diseases, diabetes, breast cancer, prostate cancer, behavioral troubles and reproductive disorders in both sexes. The aim of the present in vitro study was to evaluate the potential impact bisphenols A, B, S and F on the cell viability and testosterone release in TM3 Leydig cell line. Mice Leydig cells were cultured in the presence of different concentrations of bisphenols (0.04-50 µg.ml-1) during 24 h exposure. Quantification of the cell viability was assessed using the metabolic activity assay, while the level of testosterone in cell culture media was determined by enzyme-linked immunosorbent assay. Within the panel of substances under investigations, the higher experimental concentrations (10; 25 and 50 µg.ml-1) significantly (P<0.001) decreased Leydig cells viability, while the same doses of BPA and BPB also reduced testosterone production significantly (P<0.001). Taken together, the results of our study reported herein is a consistent whit the conclusion that higher experimental doses of bisphenols have a cytotoxic effect and could have a dose-dependent impact on testosterone production.
650    _2
$a zvířata $7 D000818
650    _2
$a benzhydrylové sloučeniny $x aplikace a dávkování $x toxicita $7 D001559
650    _2
$a buněčné linie $7 D002460
650    _2
$a viabilita buněk $x fyziologie $x účinky léků $7 D002470
650    _2
$a vztah mezi dávkou a účinkem léčiva $7 D004305
650    _2
$a endokrinní disruptory $x aplikace a dávkování $x toxicita $7 D052244
650    _2
$a estrogeny nesteroidní $x aplikace a dávkování $x toxicita $7 D004968
650    _2
$a Leydigovy buňky $x metabolismus $x účinky léků $7 D007985
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myši $7 D051379
650    _2
$a mitochondrie $x metabolismus $x účinky léků $7 D008928
650    _2
$a fenoly $x aplikace a dávkování $x toxicita $7 D010636
650    _2
$a testosteron $x antagonisté a inhibitory $x metabolismus $7 D013739
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kováčiková, Eva. $7 uzp2006361329 $u AgroBioTech Research Centre, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic
700    1_
$a Greifová, Mária. $7 xx0115338 $u Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic
700    1_
$a Kováčik, Anton. $7 xx0248548 $u Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic
700    1_
$a Libova, L. $u Faculty of Health and Social Work St. Ladislav, St. Elisabeth University of Health Care and Social Work, Bratislava, Slovak Republic
700    1_
$a Lukáč, Norbert $7 xx0248559 $u Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 68, č. 4 (2019), s. 689-693
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31342755 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20200511 $b ABA008
991    __
$a 20200602102815 $b ABA008
999    __
$a ok $b bmc $g 1530825 $s 1095526
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 68 $c 4 $d 689-693 $e 20190725 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20200511

Najít záznam

Citační ukazatele

Možnosti archivace