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Testing the methodology for a dosimetric end-to-end audit of IMRT/VMAT: results of IAEA multicentre and national studies
P. Wesolowska, D. Georg, W. Lechner, P. Kazantsev, T. Bokulic, AC. Tedgren, E. Adolfsson, AM. Campos, VGL. Alves, L. Suming, W. Hao, D. Ekendahl, I. Koniarova, W. Bulski, K. Chelminski, JLA. Samper, SP. Vinatha, S. Rakshit, S. Siri, M. Tomsejm,...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
NLK
Medline Complete (EBSCOhost)
od 1998-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1987
- MeSH
- celková dávka radioterapie MeSH
- fantomy radiodiagnostické * MeSH
- jaderná energie MeSH
- kritické orgány * MeSH
- lidé MeSH
- mezinárodní agentury MeSH
- pilotní projekty MeSH
- plánování radioterapie pomocí počítače metody MeSH
- počítačová rentgenová tomografie MeSH
- radiometrie metody normy MeSH
- radioterapie s modulovanou intenzitou metody normy MeSH
- revize kvality lékařské péče metody normy MeSH
- studie proveditelnosti MeSH
- zajištění kvality zdravotní péče MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
Introduction: Within an International Atomic Energy Agency (IAEA) co-ordinated research project (CRP), a remote end-to-end dosimetric quality audit for intensity modulated radiation therapy (IMRT)/ volumetric arc therapy (VMAT) was developed to verify the radiotherapy chain including imaging, treatment planning and dose delivery. The methodology as well as the results obtained in a multicentre pilot study and national trial runs conducted in close cooperation with dosimetry audit networks (DANs) of IAEA Member States are presented.Material and methods: A solid polystyrene phantom containing a dosimetry insert with an irregular solid water planning target volume (PTV) and organ at risk (OAR) was designed for this audit. The insert can be preloaded with radiochromic film and four thermoluminescent dosimeters (TLDs). For the audit, radiotherapy centres were asked to scan the phantom, contour the structures, create an IMRT/VMAT treatment plan and irradiate the phantom. The dose prescription was to deliver 4 Gy to the PTV in two fractions and to limit the OAR dose to a maximum of 2.8 Gy. The TLD measured doses and film measured dose distributions were compared with the TPS calculations.Results: Sixteen hospitals from 13 countries and 64 hospitals from 6 countries participated in the multicenter pilot study and in the national runs, respectively. The TLD results for the PTV were all within ±5% acceptance limit for the multicentre pilot study, whereas for national runs, 17 participants failed to meet this criterion. All measured doses in the OAR were below the treatment planning constraint. The film analysis identified seven plans in national runs below the 90% passing rate gamma criteria.Conclusion: The results proved that the methodology of the IMRT/VMAT dosimetric end-to-end audit was feasible for its intended purpose, i.e., the phantom design and materials were suitable; the phantom was easy to use and it was robust enough for shipment. Most importantly the audit methodology was capable of identifying suboptimal IMRT/VMAT delivery.
Beijing Cancer Hospital Beijing China
Cancer Centre Helsinki University Hospital Helsinki Finland
Chinese Centre for Disease Control and Prevention Beijing China
CHU Charleroi Hopital Andre Vesale Montigny le Tilleul Belgium
Imaging and Radiation Oncology Core Houston QA Centre Anderson Cancer Centre Houston TX USA
Instituto Nacional De Câncer Rio De Janeiro Brazil
International Atomic Energy Agency Vienna Austria
Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology Warsaw Poland
National Institute of Oncology and Radiobiology Havana Cuba
National Radiation Protection Institute Prague Czech Republic
SSDL Bureau of Radiation and Medical Devices Department of Medical Science Nonthaburi Thailand
University of Leeds St James's University Hospital Leeds United Kingdom
Citace poskytuje Crossref.org
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- $a Introduction: Within an International Atomic Energy Agency (IAEA) co-ordinated research project (CRP), a remote end-to-end dosimetric quality audit for intensity modulated radiation therapy (IMRT)/ volumetric arc therapy (VMAT) was developed to verify the radiotherapy chain including imaging, treatment planning and dose delivery. The methodology as well as the results obtained in a multicentre pilot study and national trial runs conducted in close cooperation with dosimetry audit networks (DANs) of IAEA Member States are presented.Material and methods: A solid polystyrene phantom containing a dosimetry insert with an irregular solid water planning target volume (PTV) and organ at risk (OAR) was designed for this audit. The insert can be preloaded with radiochromic film and four thermoluminescent dosimeters (TLDs). For the audit, radiotherapy centres were asked to scan the phantom, contour the structures, create an IMRT/VMAT treatment plan and irradiate the phantom. The dose prescription was to deliver 4 Gy to the PTV in two fractions and to limit the OAR dose to a maximum of 2.8 Gy. The TLD measured doses and film measured dose distributions were compared with the TPS calculations.Results: Sixteen hospitals from 13 countries and 64 hospitals from 6 countries participated in the multicenter pilot study and in the national runs, respectively. The TLD results for the PTV were all within ±5% acceptance limit for the multicentre pilot study, whereas for national runs, 17 participants failed to meet this criterion. All measured doses in the OAR were below the treatment planning constraint. The film analysis identified seven plans in national runs below the 90% passing rate gamma criteria.Conclusion: The results proved that the methodology of the IMRT/VMAT dosimetric end-to-end audit was feasible for its intended purpose, i.e., the phantom design and materials were suitable; the phantom was easy to use and it was robust enough for shipment. Most importantly the audit methodology was capable of identifying suboptimal IMRT/VMAT delivery.
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- $a Georg, Dietmar $u Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria. Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Vienna, Austria.
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