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Embryonic Cerebellar Graft Morphology Differs in Two Mouse Models of Cerebellar Degeneration
Z. Purkartova, F. Tichanek, Y. Kolinko, J. Cendelin,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
GAUK 716217
Grantová Agentura, Univerzita Karlova
LO1503
Ministry of education, youth and sport of the Czech Republic
Q39
Univerzita Karlova v Praze
SVV 260394
Univerzita Karlova v Praze
NLK
ProQuest Central
od 2002-03-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2002-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2002-03-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2002-03-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2002-03-01 do Před 1 rokem
- MeSH
- modely nemocí na zvířatech * MeSH
- mozeček fyziologie transplantace MeSH
- myši - mutanty neurologické MeSH
- myši inbrední C57BL MeSH
- myši inbrední CBA MeSH
- myši MeSH
- nemoci mozečku patologie terapie MeSH
- neurodegenerativní nemoci patologie terapie MeSH
- přežívání štěpu fyziologie MeSH
- transplantace fetální tkáně metody MeSH
- transplantace mozkové tkáně metody MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Cerebellar diseases causing substantial cell loss often lead to severe functional deficits and restoration of cerebellar function is difficult. Neurotransplantation therapy could become a hopeful method, but there are still many limitations and unknown aspects. Studies in a variety of cerebellar mutant mice reflecting heterogeneity of human cerebellar degenerations show promising results as well as new problems and questions to be answered. The aim of this work was to compare the development of embryonic cerebellar grafts in adult B6CBA Lurcher and B6.BR pcd mutant mice and strain-matched healthy wild type mice. Performance in the rotarod test, graft survival, structure, and volume was examined 2 months after the transplantation or sham-operation. The grafts survived in most of the mice of all types. In both B6CBA and B6.BR wild type mice and in pcd mice, colonization of the host's cerebellum was a common finding, while in Lurcher mice, the grafts showed a low tendency to infiltrate the host's cerebellar tissue. There were no significant differences in graft volume between mutant and wild type mice. Nevertheless, B6CBA mice had smaller grafts than their B6.BR counterparts. The transplantation did not improve the performance in the rotarod test. The study showed marked differences in graft integration into the host's cerebellum in two types of cerebellar mutants, suggesting disease-specific factors influencing graft fate.
Citace poskytuje Crossref.org
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- $a Purkartová, Zdeňka, $u Department of Pathological Physiology, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00, Plzeň, Czech Republic. $d 1974- $7 xx0326689
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- $a Cerebellar diseases causing substantial cell loss often lead to severe functional deficits and restoration of cerebellar function is difficult. Neurotransplantation therapy could become a hopeful method, but there are still many limitations and unknown aspects. Studies in a variety of cerebellar mutant mice reflecting heterogeneity of human cerebellar degenerations show promising results as well as new problems and questions to be answered. The aim of this work was to compare the development of embryonic cerebellar grafts in adult B6CBA Lurcher and B6.BR pcd mutant mice and strain-matched healthy wild type mice. Performance in the rotarod test, graft survival, structure, and volume was examined 2 months after the transplantation or sham-operation. The grafts survived in most of the mice of all types. In both B6CBA and B6.BR wild type mice and in pcd mice, colonization of the host's cerebellum was a common finding, while in Lurcher mice, the grafts showed a low tendency to infiltrate the host's cerebellar tissue. There were no significant differences in graft volume between mutant and wild type mice. Nevertheless, B6CBA mice had smaller grafts than their B6.BR counterparts. The transplantation did not improve the performance in the rotarod test. The study showed marked differences in graft integration into the host's cerebellum in two types of cerebellar mutants, suggesting disease-specific factors influencing graft fate.
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- $a Kolinko, Yaroslav $u Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Karlovarská 48, 301 66, Plzeň, Czech Republic. Laboratory of Quantitative Histology, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Karlovarská 48, 301 66, Plzeň, Czech Republic.
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- $a Cendelin, Jan $u Department of Pathological Physiology, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00, Plzeň, Czech Republic. jan.cendelin@lfp.cuni.cz. Laboratory of Neurodegenerative Disorders, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00, Plzeň, Czech Republic. jan.cendelin@lfp.cuni.cz.
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