-
Je něco špatně v tomto záznamu ?
Exposure to dolutegravir in pregnant women living with HIV in Central and Eastern Europe and neighboring countries - data from the ECEE Network Group
D. Gokengin, I. Aho, F. Sarıgül Yıldırım, P. Bukovinova, E. Siwak, A. Papadopoulos, D. Sedlacek, J. Kowalska,
Jazyk angličtina Země Polsko
Typ dokumentu časopisecké články, multicentrická studie
NLK
Directory of Open Access Journals
od 2007
Free Medical Journals
od 2008
ProQuest Central
od 2010-01-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2007
PubMed
31392711
DOI
10.5603/gp.2019.0070
Knihovny.cz E-zdroje
- MeSH
- heterocyklické sloučeniny tricyklické terapeutické užití MeSH
- HIV infekce farmakoterapie MeSH
- infekční komplikace v těhotenství farmakoterapie MeSH
- inhibitory HIV-integrasy terapeutické užití MeSH
- kyselina listová terapeutické užití MeSH
- lidé MeSH
- novorozenec MeSH
- průzkumy a dotazníky MeSH
- spotřeba léčiv statistika a číselné údaje MeSH
- těhotenství MeSH
- výsledek těhotenství MeSH
- zpožděný efekt prenatální expozice MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Evropa MeSH
OBJECTIVES: The purpose of this study was to investigate dolutegravir (DTG) use among women and exposure to DTG during pregnancy in real world in Central and Eastern Europe and neighboring countries. MATERIAL AND METHODS: Centres from 20 countries included in the Euroguidelines in Central and Eastern Europe (ECEE) Network and Finland were asked to complete an on-line questionnaire. RESULTS: Seven centres from Czech Republic, Finland, Greece, Poland, Slovakia, and Turkey provided detailed information. DTG exposure was reported in 415 women, of which 26 were during pregnancy. Of those, 22 were on DTG at the time of conception and 4 had started DTG during pregnancy. Few women had conventional risk factors. The data on folic acid usage was unknown for eight women; 14 were using and four were not using folic acid. Four pregnancies were ongoing at the time of the study and of those with an outcome, 77.3% resulted with term, 13.6% preterm delivery, 4.5% spontaneous and 4.5% medical abortion. CONCLUSIONS: The DTG signal report indicates the importance of safety research for drug use in pregnancy and highlights the urgent need for systematic surveillance of pregnancy outcomes and neonatal surveillance. Countries with low- or moderate HIV prevalence should be included in studies reviewing pregnancy outcomes and in any surveillance system to ensure the accuracy of drug safety revision.
Department of Infectious Diseases and Geographical Medicine UH Bratislava Slovakia
Ege University Faculty of Medicine Department of Infectious Diseases Izmir Turkey
Health Science University Antalya Education and Training Hospital Antalya Turkey
Helsinki University Hospital Helsinki Finland
HIV Centre Department of Infectious Diseases University Hospital Plzen Czech Republic
Hospital for Infectious Diseases HIV Out Patient Clinic Warsaw Poland
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20006062
- 003
- CZ-PrNML
- 005
- 20200528112609.0
- 007
- ta
- 008
- 200511s2019 pl f 000 0| eng|
- 009
- AR
- 024 7_
- $a 10.5603/GP.2019.0070 $2 doi
- 035 __
- $a (PubMed)31392711
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a pl
- 100 1_
- $a Gokengin, Deniz $u Ege University Faculty of Medicine Department of Infectious Diseases, Izmir, Turkey. gkengin61@gmail.com.
- 245 10
- $a Exposure to dolutegravir in pregnant women living with HIV in Central and Eastern Europe and neighboring countries - data from the ECEE Network Group / $c D. Gokengin, I. Aho, F. Sarıgül Yıldırım, P. Bukovinova, E. Siwak, A. Papadopoulos, D. Sedlacek, J. Kowalska,
- 520 9_
- $a OBJECTIVES: The purpose of this study was to investigate dolutegravir (DTG) use among women and exposure to DTG during pregnancy in real world in Central and Eastern Europe and neighboring countries. MATERIAL AND METHODS: Centres from 20 countries included in the Euroguidelines in Central and Eastern Europe (ECEE) Network and Finland were asked to complete an on-line questionnaire. RESULTS: Seven centres from Czech Republic, Finland, Greece, Poland, Slovakia, and Turkey provided detailed information. DTG exposure was reported in 415 women, of which 26 were during pregnancy. Of those, 22 were on DTG at the time of conception and 4 had started DTG during pregnancy. Few women had conventional risk factors. The data on folic acid usage was unknown for eight women; 14 were using and four were not using folic acid. Four pregnancies were ongoing at the time of the study and of those with an outcome, 77.3% resulted with term, 13.6% preterm delivery, 4.5% spontaneous and 4.5% medical abortion. CONCLUSIONS: The DTG signal report indicates the importance of safety research for drug use in pregnancy and highlights the urgent need for systematic surveillance of pregnancy outcomes and neonatal surveillance. Countries with low- or moderate HIV prevalence should be included in studies reviewing pregnancy outcomes and in any surveillance system to ensure the accuracy of drug safety revision.
- 650 _2
- $a spotřeba léčiv $x statistika a číselné údaje $7 D004363
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a kyselina listová $x terapeutické užití $7 D005492
- 650 _2
- $a HIV infekce $x farmakoterapie $7 D015658
- 650 _2
- $a inhibitory HIV-integrasy $x terapeutické užití $7 D019428
- 650 _2
- $a heterocyklické sloučeniny tricyklické $x terapeutické užití $7 D006575
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a novorozenec $7 D007231
- 650 _2
- $a těhotenství $7 D011247
- 650 _2
- $a infekční komplikace v těhotenství $x farmakoterapie $7 D011251
- 650 _2
- $a výsledek těhotenství $7 D011256
- 650 _2
- $a zpožděný efekt prenatální expozice $7 D011297
- 650 _2
- $a průzkumy a dotazníky $7 D011795
- 651 _2
- $a Evropa $7 D005060
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 700 1_
- $a Aho, Inka $u Helsinki University Hospital, Helsinki, Finland.
- 700 1_
- $a Sarıgül Yıldırım, Figen $u Health Science University Antalya Education and Training Hospital, Antalya, Turkey.
- 700 1_
- $a Bukovinova, Pavla $u Department of Infectious Diseases and Geographical Medicine UH, Bratislava, Slovakia.
- 700 1_
- $a Siwak, Ewa $u Hospital for Infectious Diseases, HIV Out-Patient Clinic, Warsaw, Poland.
- 700 1_
- $a Papadopoulos, Antonios $u University Hospital, Athens, Greece.
- 700 1_
- $a Sedlacek, Dalibor $u HIV Centre, Department of Infectious Diseases, University Hospital, Plzen, Czech Republic.
- 700 1_
- $a Kowalska, Justyna $u Hospital for Infectious Diseases, HIV Out-Patient Clinic, Warsaw, Poland. Medical University of Warsaw, Department of Adult's Infectious Diseases, Warsaw, Poland.
- 773 0_
- $w MED00001927 $t Ginekologia polska $x 2543-6767 $g Roč. 90, č. 7 (2019), s. 411-415
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31392711 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200511 $b ABA008
- 991 __
- $a 20200528112607 $b ABA008
- 999 __
- $a ok $b bmc $g 1524920 $s 1096118
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 90 $c 7 $d 411-415 $e - $i 2543-6767 $m Ginekologia polska $n Ginekol Pol $x MED00001927
- LZP __
- $a Pubmed-20200511