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Pharmacogenomic analyses of sunitinib in patients with pancreatic neuroendocrine tumors

N. Fazio, JF. Martini, AE. Croitoru, M. Schenker, S. Li, B. Rosbrook, K. Fernandez, J. Tomasek, E. Thiis-Evensen, M. Kulke, E. Raymond,

. 2019 ; 15 (17) : 1997-2007. [pub] 20190514

Language English Country Great Britain

Document type Clinical Trial, Phase IV, Journal Article

Persistent link   https://www.medvik.cz/link/bmc20006367
E-resources Online Full text

NLK PubMed Central from 2015 to 1 year ago
ProQuest Central from 2005-02-01 to 2020-12-31
Health & Medicine (ProQuest) from 2005-02-01 to 2020-12-31

Links

PubMed 31084373
DOI 10.2217/fon-2018-0934
Knihovny.cz E-resources

Aim: Evaluate associations between clinical outcomes and SNPs in patients with well-differentiated pancreatic neuroendocrine tumors receiving sunitinib. Patients & methods: Kaplan-Meier and Cox proportional hazards models were used to analyze the association between SNPs and survival outcomes using data from a sunitinib Phase IV (genotyped, n = 56) study. Fisher's exact test was used to analyze objective response rate and genotype associations. Results: After multiplicity adjustment, progression-free and overall survivals were not significantly correlated with SNPs; however, a higher objective response rate was significantly associated with IL1B rs16944 G/A versus G/G (46.4 vs 4.5%; p = 0.001). Conclusion:IL1B SNPs may predict treatment response in patients with pancreatic neuroendocrine tumors. VEGF pathway SNPs are potentially associated with survival outcomes.

References provided by Crossref.org

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$a Aim: Evaluate associations between clinical outcomes and SNPs in patients with well-differentiated pancreatic neuroendocrine tumors receiving sunitinib. Patients & methods: Kaplan-Meier and Cox proportional hazards models were used to analyze the association between SNPs and survival outcomes using data from a sunitinib Phase IV (genotyped, n = 56) study. Fisher's exact test was used to analyze objective response rate and genotype associations. Results: After multiplicity adjustment, progression-free and overall survivals were not significantly correlated with SNPs; however, a higher objective response rate was significantly associated with IL1B rs16944 G/A versus G/G (46.4 vs 4.5%; p = 0.001). Conclusion:IL1B SNPs may predict treatment response in patients with pancreatic neuroendocrine tumors. VEGF pathway SNPs are potentially associated with survival outcomes.
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