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Complex response of the organism to trauma

Renáta Ječmínková, Vladimír Ječmínek, Jan Divák, Marcela Káňová, Ondřej Jor, Kamil Tomášek, Leopold Pleva, David Holeš

. 2018 ; 26 (2) : 62-66.

Language English Country Czech Republic

Document type Review

Persistent link   https://www.medvik.cz/link/bmc20010336

INTRODUCTION: Severe trauma leads to a disruption of the external and internal barrier systems of the affected organism followed by a complex and highly organized reaction triggered by the release of signal molecules from the damaged tissues. These initiate both the activation of the innate immune system and the stimulation of acquired immunity and affect the nervous and hormonal systems. The effort of the organism is to maintain balance and adequacy of this complex reaction and to prevent excessive escalation of originally protective physiological processes. OBJECTIVE: The aim of this work is to provide a comprehensive view of the complex issue of subsequent changes in the body after a severe trauma METHODOLOGY: Review article. CONCLUSION: More and more detailed knowledge and methods of detecting the pathophysiological processes of the body in connection with severe trauma may be the key to other possible therapeutic interventions for these injured patients.

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