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Polymer-free sirolimus-eluting stent use in Europe and Asia: Ethnic differences in demographics and clinical outcomes

F. Krackhardt, M. Waliszewski, WA. Wan Ahmad, V. Kočka, P. Toušek, B. Janek, M. Trenčan, P. Krajči, F. Lozano, K. Garcia-San Roman, I. Otaegui Irurueta, B. Garcia Del Blanco, L. Wachowiak, V. Vilalta Del Olmo, E. Fernandez Nofrerías, M. Ho Jeong,...

. 2020 ; 15 (1) : e0226606. [pub] 20200113

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc20023236

BACKGROUND: The objective of this study was to assess regional and ethnic differences in an unselected patient population treated with polymer-free sirolimus-eluting stents (PF-SES) in Asia and Europe. METHODS: Two all-comers observational studies based on the same protocol (ClinicalTrials.gov Identifiers: NCT02629575 and NCT02905214) were combined for data analysis to assure sufficient statistical power. The primary endpoint was the accumulated target lesion revascularization (TLR) rate at 9-12 months. RESULTS: Of the total population of 7243 patients, 44.0% (3186) were recruited in the Mediterranean region and 32.0% (2317) in central Europe. The most prominent Asian region was South Korea (17.6%, 1274) followed by Malaysia (5.7%, 413). Major cardiovascular risk factors varied significantly across regions. The overall rates for accumulated TLR and MACE were low with 2.2% (140/6374) and 4.4% (279/6374), respectively. In ACS patients, there were no differences in terms of MACE, TLR, MI and accumulated mortality between the investigated regions. Moreover, dual antiplatelet therapy (DAPT) regimens were substantially longer in Asian countries even in patients with stable coronary artery disease as compared to those in Europe. CONCLUSIONS: PF-SES angioplasty is associated with low clinical event rates in all regions. Further reductions in clinical event rates seem to be associated with longer DAPT regimens.

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$a BACKGROUND: The objective of this study was to assess regional and ethnic differences in an unselected patient population treated with polymer-free sirolimus-eluting stents (PF-SES) in Asia and Europe. METHODS: Two all-comers observational studies based on the same protocol (ClinicalTrials.gov Identifiers: NCT02629575 and NCT02905214) were combined for data analysis to assure sufficient statistical power. The primary endpoint was the accumulated target lesion revascularization (TLR) rate at 9-12 months. RESULTS: Of the total population of 7243 patients, 44.0% (3186) were recruited in the Mediterranean region and 32.0% (2317) in central Europe. The most prominent Asian region was South Korea (17.6%, 1274) followed by Malaysia (5.7%, 413). Major cardiovascular risk factors varied significantly across regions. The overall rates for accumulated TLR and MACE were low with 2.2% (140/6374) and 4.4% (279/6374), respectively. In ACS patients, there were no differences in terms of MACE, TLR, MI and accumulated mortality between the investigated regions. Moreover, dual antiplatelet therapy (DAPT) regimens were substantially longer in Asian countries even in patients with stable coronary artery disease as compared to those in Europe. CONCLUSIONS: PF-SES angioplasty is associated with low clinical event rates in all regions. Further reductions in clinical event rates seem to be associated with longer DAPT regimens.
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$a Waliszewski, Matthias $u Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Campus Virchow, Berlin, Germany. Medical Scientific Affairs, B.Braun Melsungen AG, Berlin, Germany.
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$a Wan Ahmad, Wan Azman $u University Malaya Medical Centre, Kuala Lumpur, Malaysia.
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$a Kočka, Viktor $u University Hospital Královské Vinohrady Prague, Czech Republic.
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$a Toušek, Petr $u University Hospital Královské Vinohrady Prague, Czech Republic.
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$a Janek, Bronislav $u IKEM Prague, Czech Republic.
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$a Trenčan, Milan $u SÚSCCH, a.s. Banská Bystrica, Slovak Republic.
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$a Lozano, Fernando $u Hospital General Universitario de Ciudad Real, Ciudad Real, Spain.
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$a Otaegui Irurueta, Imanol $u Hospital Universitari Vall d'Hebron Barcelona, Spain.
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$a Garcia Del Blanco, Bruno $u Hospital Universitari Vall d'Hebron Barcelona, Spain.
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$a Wachowiak, Lucie $u Medical Scientific Affairs, B.Braun France, Saint-Cloud, France.
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$a Vilalta Del Olmo, Victoria $u Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
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$a Ho Jeong, Myung $u Chonnam National University, Gwangju, South Korea.
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$a Jung, Byung-Chun $u Daegu Fatima Hospital, Daegu, South Korea.
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$a Han, Kyu-Rock $u Kangdong Sacred Heart Hospital, Kangdong, South Korea.
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$a Piot, Christophe $u Clinique du Millénaire, Montpellier, France.
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$a Sebagh, Laurent $u Clinique Turin, Paris, France.
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$a Rischner, Jérôme $u Hôpital Albert Schweitzer Colmar, France.
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$a Pansieri, Michel $u Centre Hospitalier d'Avignon, Avignon, France.
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$a Leschke, Matthias $u Städtische Kliniken Esslingen, Esslingen, Germany.
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$a Ahn, Tae Hoon $u Gachon University Gil Medical Center, Incheon, South Korea.
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