-
Je něco špatně v tomto záznamu ?
Gastric cancer during pregnancy: A report on 13 cases and review of the literature with focus on chemotherapy during pregnancy
C. Maggen, CA. Lok, E. Cardonick, M. van Gerwen, PB. Ottevanger, IA. Boere, M. Koskas, MJ. Halaska, R. Fruscio, MM. Gziri, PO. Witteveen, K. Van Calsteren, F. Amant, International Network on Cancer, Infertility and Pregnancy (INCIP),
Jazyk angličtina Země Spojené státy americké
Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
G070514N
Fonds Wetenschappelijk Onderzoek - International
00064173
Kralovske Vinohrady University Hospital - International
647047
H2020 European Research Council - International
European Society of Gynecological Oncology - International
Charles University - International
Odkazy
PubMed
31529466
DOI
10.1111/aogs.13731
Knihovny.cz E-zdroje
- MeSH
- antitumorózní látky škodlivé účinky MeSH
- dospělí MeSH
- lidé MeSH
- maternofetální výměna látek MeSH
- nádorové komplikace v těhotenství farmakoterapie MeSH
- nádory žaludku farmakoterapie MeSH
- novorozenec MeSH
- předčasný porod MeSH
- preeklampsie chemicky indukované MeSH
- protokoly antitumorózní kombinované chemoterapie škodlivé účinky MeSH
- růstová retardace plodu chemicky indukované MeSH
- těhotenství MeSH
- výsledek těhotenství * MeSH
- zpožděný efekt prenatální expozice * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
INTRODUCTION: Gastric cancer during pregnancy is extremely rare and data on optimal treatment and possible chemotherapeutic regimens are scarce. The aim of this study is to describe the obstetric and maternal outcome of women with gastric cancer during pregnancy and review the literature on antenatal chemotherapy for gastric cancer. MATERIAL AND METHODS: Treatment and outcome of patients registered in the International Network on Cancer, Infertility and Pregnancy database with gastric cancer diagnosed during pregnancy were analyzed. RESULTS: In total, 13 women with gastric cancer during pregnancy were registered between 2002 and 2018. Median gestational age at diagnosis was 22 weeks (range 6-30 weeks). Twelve women were diagnosed with advanced disease and died within 2 years after pregnancy, most within 6 months. In total, eight out of 10 live births ended in a preterm delivery because of preeclampsia, maternal deterioration, or therapy planning. Two out of six women who initiated chemotherapy during pregnancy delivered at term. Two neonates prenatally exposed to chemotherapy were growth restricted and one of them developed a systemic infection with brain abscess after preterm delivery for preeclampsia 2 weeks after chemotherapy. No malformations were reported. CONCLUSIONS: The prognosis of gastric cancer during pregnancy is poor, mainly due to advanced disease at diagnosis, emphasizing the need for early diagnosis. Antenatal chemotherapy can be considered to reach fetal maturity, taking possible complications such as growth restriction, preterm delivery, and hematopoietic suppression at birth into account.
Clinic of Obstetrics and Gynecology University of Milan Bicocca San Gerardo Hospital Monza Italy
Department of Medical Oncology Radboud University Nijmegen Medical Center Nijmegen The Netherlands
Department of Obstetrics and Gynecology Cooper University Health Care Camden NJ USA
Department of Obstetrics Cliniques Universitaires St Luc UCL Sint Lambrechts Woluwe Belgium
Gynecologic Oncology Bichat University Hospital Paris Diderot University Paris France
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20023249
- 003
- CZ-PrNML
- 005
- 20201214125558.0
- 007
- ta
- 008
- 201125s2020 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/aogs.13731 $2 doi
- 035 __
- $a (PubMed)31529466
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Maggen, Charlotte $u Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium. Department of Oncology, KU Leuven, Leuven, Belgium.
- 245 10
- $a Gastric cancer during pregnancy: A report on 13 cases and review of the literature with focus on chemotherapy during pregnancy / $c C. Maggen, CA. Lok, E. Cardonick, M. van Gerwen, PB. Ottevanger, IA. Boere, M. Koskas, MJ. Halaska, R. Fruscio, MM. Gziri, PO. Witteveen, K. Van Calsteren, F. Amant, International Network on Cancer, Infertility and Pregnancy (INCIP),
- 520 9_
- $a INTRODUCTION: Gastric cancer during pregnancy is extremely rare and data on optimal treatment and possible chemotherapeutic regimens are scarce. The aim of this study is to describe the obstetric and maternal outcome of women with gastric cancer during pregnancy and review the literature on antenatal chemotherapy for gastric cancer. MATERIAL AND METHODS: Treatment and outcome of patients registered in the International Network on Cancer, Infertility and Pregnancy database with gastric cancer diagnosed during pregnancy were analyzed. RESULTS: In total, 13 women with gastric cancer during pregnancy were registered between 2002 and 2018. Median gestational age at diagnosis was 22 weeks (range 6-30 weeks). Twelve women were diagnosed with advanced disease and died within 2 years after pregnancy, most within 6 months. In total, eight out of 10 live births ended in a preterm delivery because of preeclampsia, maternal deterioration, or therapy planning. Two out of six women who initiated chemotherapy during pregnancy delivered at term. Two neonates prenatally exposed to chemotherapy were growth restricted and one of them developed a systemic infection with brain abscess after preterm delivery for preeclampsia 2 weeks after chemotherapy. No malformations were reported. CONCLUSIONS: The prognosis of gastric cancer during pregnancy is poor, mainly due to advanced disease at diagnosis, emphasizing the need for early diagnosis. Antenatal chemotherapy can be considered to reach fetal maturity, taking possible complications such as growth restriction, preterm delivery, and hematopoietic suppression at birth into account.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a antitumorózní látky $x škodlivé účinky $7 D000970
- 650 _2
- $a protokoly antitumorózní kombinované chemoterapie $x škodlivé účinky $7 D000971
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a růstová retardace plodu $x chemicky indukované $7 D005317
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a novorozenec $7 D007231
- 650 _2
- $a maternofetální výměna látek $7 D008431
- 650 _2
- $a preeklampsie $x chemicky indukované $7 D011225
- 650 _2
- $a těhotenství $7 D011247
- 650 _2
- $a nádorové komplikace v těhotenství $x farmakoterapie $7 D011252
- 650 12
- $a výsledek těhotenství $7 D011256
- 650 _2
- $a předčasný porod $7 D047928
- 650 12
- $a zpožděný efekt prenatální expozice $7 D011297
- 650 _2
- $a nádory žaludku $x farmakoterapie $7 D013274
- 655 _2
- $a kazuistiky $7 D002363
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Lok, Christianne A $u Center for Gynecological Oncology Amsterdam, Antoni van Leeuwenhoek - Netherlands Cancer Institute, Amsterdam, The Netherlands.
- 700 1_
- $a Cardonick, Elyce $u Department of Obstetrics and Gynecology, Cooper, University Health Care, Camden, NJ, USA.
- 700 1_
- $a van Gerwen, Mathilde $u Center for Gynecological Oncology Amsterdam, Antoni van Leeuwenhoek - Netherlands Cancer Institute, Amsterdam, The Netherlands. Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
- 700 1_
- $a Ottevanger, Petronella B $u Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
- 700 1_
- $a Boere, Ingrid A $u Department of Medical Oncology, Erasmus MC Cancer, Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a Koskas, Martin $u Gynecologic Oncology, Bichat University Hospital, Paris Diderot University, Paris, France.
- 700 1_
- $a Halaska, Michael J $u Faculty Hospital Kralovske, Vinohrady and 3rd Medical Faculty, Charles University, Prague, Czech Republic.
- 700 1_
- $a Fruscio, Robert $u Clinic of Obstetrics and Gynecology, University of Milan - Bicocca, San Gerardo Hospital, Monza, Italy.
- 700 1_
- $a Gziri, Mina M $u Department of Obstetrics, Cliniques Universitaires St Luc, UCL, Sint-Lambrechts-Woluwe, Belgium.
- 700 1_
- $a Witteveen, Petronella O $u Department of Medical Oncology, Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
- 700 1_
- $a Van Calsteren, Kristel $u Department of Obstetrics, University Hospitals Leuven, Leuven and Department of Development and regeneration, KU Leuven, Leuven, Belgium.
- 700 1_
- $a Amant, Frédéric $u Department of Oncology, KU Leuven, Leuven, Belgium. Center for Gynecological Oncology Amsterdam, Antoni van Leeuwenhoek - Netherlands Cancer Institute, Amsterdam, The Netherlands. Center for Gynecological Oncology Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
- 710 2_
- $a International Network on Cancer, Infertility and Pregnancy (INCIP)
- 773 0_
- $w MED00009026 $t Acta obstetricia et gynecologica Scandinavica $x 1600-0412 $g Roč. 99, č. 1 (2020), s. 79-88
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31529466 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20201214125557 $b ABA008
- 999 __
- $a ok $b bmc $g 1595568 $s 1113925
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 99 $c 1 $d 79-88 $e 20191016 $i 1600-0412 $m Acta obstetricia et gynecologica Scandinavica $n Acta Obstet Gynecol Scand $x MED00009026
- GRA __
- $a G070514N $p Fonds Wetenschappelijk Onderzoek $2 International
- GRA __
- $a 00064173 $p Kralovske Vinohrady University Hospital $2 International
- GRA __
- $a 647047 $p H2020 European Research Council $2 International
- GRA __
- $p European Society of Gynecological Oncology $2 International
- GRA __
- $p Charles University $2 International
- LZP __
- $a Pubmed-20201125