• Je něco špatně v tomto záznamu ?

Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides

JA. Hubacek, D. Pelclova, D. Dlouha, P. Mikuska, S. Dvorackova, S. Vlckova, Z. Fenclova, J. Ondracek, M. Kostejn, J. Schwarz, A. Popov, K. Krumal, V. Lanska, P. Coufalik, S. Zakharov, V. Zdimal,

. 2019 ; 57 (6) : 741-744. [pub] 20190328

Jazyk angličtina Země Japonsko

Typ dokumentu srovnávací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20023459

The aim of this study was to ascertain whether long-term occupational exposure to nanoparticles would affect relative leukocyte telomere length (LrTL). We analysed occupational exposure to size-resolved aerosol particles, with special emphasis on nanoparticles at two workshops: i/ the production of nanocomposites containing metal oxides; ii/ laboratory to test experimental exposure of nano-CuO to rodents. Thirty five exposed researchers (age 39.5 ± 12.6 yr; exposure duration 6.0 ± 3.7 yr) and 43 controls (40.4 ± 10.5 yr) were examined. LrTL did not significantly (p=0.14) differ between the exposed researchers (0.92 ± 0.13) and controls (0.86 ± 0.15). In addition, no significant correlation (r=-0.22, p=0.22) was detected between the duration of occupational exposure and LrTL. The results remained non-significant after multiple adjustments for age, sex and smoking status. Our pilot results suggest that relative leukocyte telomere length is not affected by occupational exposure to nanoparticles.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20023459
003      
CZ-PrNML
005      
20201214130108.0
007      
ta
008      
201125s2019 ja f 000 0|eng||
009      
AR
024    7_
$a 10.2486/indhealth.2018-0146 $2 doi
035    __
$a (PubMed)30918138
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ja
100    1_
$a Hubacek, Jaroslav A $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Czech Republic.
245    10
$a Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides / $c JA. Hubacek, D. Pelclova, D. Dlouha, P. Mikuska, S. Dvorackova, S. Vlckova, Z. Fenclova, J. Ondracek, M. Kostejn, J. Schwarz, A. Popov, K. Krumal, V. Lanska, P. Coufalik, S. Zakharov, V. Zdimal,
520    9_
$a The aim of this study was to ascertain whether long-term occupational exposure to nanoparticles would affect relative leukocyte telomere length (LrTL). We analysed occupational exposure to size-resolved aerosol particles, with special emphasis on nanoparticles at two workshops: i/ the production of nanocomposites containing metal oxides; ii/ laboratory to test experimental exposure of nano-CuO to rodents. Thirty five exposed researchers (age 39.5 ± 12.6 yr; exposure duration 6.0 ± 3.7 yr) and 43 controls (40.4 ± 10.5 yr) were examined. LrTL did not significantly (p=0.14) differ between the exposed researchers (0.92 ± 0.13) and controls (0.86 ± 0.15). In addition, no significant correlation (r=-0.22, p=0.22) was detected between the duration of occupational exposure and LrTL. The results remained non-significant after multiple adjustments for age, sex and smoking status. Our pilot results suggest that relative leukocyte telomere length is not affected by occupational exposure to nanoparticles.
650    _2
$a dospělí $7 D000328
650    _2
$a látky znečišťující vzduch v pracovním prostředí $x škodlivé účinky $7 D000395
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a leukocyty $7 D007962
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a kovové nanočástice $x škodlivé účinky $7 D053768
650    _2
$a lidé středního věku $7 D008875
650    _2
$a pracovní expozice $x škodlivé účinky $7 D016273
650    _2
$a oxidy $7 D010087
650    12
$a výzkumní pracovníci $7 D012108
650    _2
$a zkracování telomer $x účinky léků $7 D059506
651    _2
$a Česká republika $x epidemiologie $7 D018153
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
700    1_
$a Pelclova, Daniela $u Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
700    1_
$a Dlouha, Dana $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Czech Republic.
700    1_
$a Mikuska, Pavel $u Institute of Analytical Chemistry of the CAS, Czech Republic.
700    1_
$a Dvorackova, Stepanka $u Department of Machining and Assembly, Department of Engineering Technology, Department of Material Science, Faculty of Mechanical Engineering, Technical University in Liberec, Czech Republic.
700    1_
$a Vlckova, Stepanka $u Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
700    1_
$a Fenclova, Zdenka $u Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
700    1_
$a Ondracek, Jakub $u Institute of Chemical Process Fundamentals CAS, Czech Republic.
700    1_
$a Kostejn, Martin $u Institute of Chemical Process Fundamentals CAS, Czech Republic.
700    1_
$a Schwarz, Jaroslav $u Institute of Chemical Process Fundamentals CAS, Czech Republic.
700    1_
$a Popov, Alex $u Department of Machining and Assembly, Department of Engineering Technology, Department of Material Science, Faculty of Mechanical Engineering, Technical University in Liberec, Czech Republic.
700    1_
$a Krumal, Kamil $u Institute of Analytical Chemistry of the CAS, Czech Republic.
700    1_
$a Lanska, Vera $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Czech Republic.
700    1_
$a Coufalik, Pavel $u Institute of Analytical Chemistry of the CAS, Czech Republic.
700    1_
$a Zakharov, Sergej $u Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
700    1_
$a Zdimal, Vladimir $u Institute of Chemical Process Fundamentals CAS, Czech Republic.
773    0_
$w MED00002229 $t Industrial health $x 1880-8026 $g Roč. 57, č. 6 (2019), s. 741-744
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30918138 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201125 $b ABA008
991    __
$a 20201214130107 $b ABA008
999    __
$a ok $b bmc $g 1595778 $s 1114135
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 57 $c 6 $d 741-744 $e 20190328 $i 1880-8026 $m Industrial Health $n Ind Health $x MED00002229
LZP    __
$a Pubmed-20201125

Najít záznam

Citační ukazatele

Možnosti archivace